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Audiovisual integration and whole-brain networks in preterm and full-term
neonates: A two-layer multiplex network perspective on structural and functional
connectivity
#MMPMID41113938
Quinones JF
; Gießing C
; Heep A
; Hildebrandt A
Imaging Neurosci (Camb)
2025[]; 3
(?): ? PMID41113938
show ga
Audiovisual integration (AVI) is linked to the development of several cognitive
abilities, rendering it a vehicle to better understand and anticipate a wide
range of sequelae associated with preterm (PT) birth. In the present study, we
aimed to complement the scarce literature on PT birth and AVI early in life, by
investigating neonatal brain networks encompassing areas reported in the infant
AVI literature. We used data from the Developing Human Connectome Project
(http://www.developingconnectome.org/) to build two localized and one whole-brain
connectomes from functional and structural connectivity data. Using graph
analysis on a multiplex structural-functional brain network, we investigated the
association between prematurity and (1) the edges present in functional and
structural networks, (2) the integration and segregation properties of functional
and structural networks, and (3) the inter-layer assortativity. We found
substantial differences between PT and full-term (FT) neonates in the edges of
the structural network at the whole-brain level and in one localized connectome.
Across parcellation schemes, associations between prematurity and network
efficiency were different, but similar inter-layer metrics were observed. In an
exploratory analysis, we further showed lower functional connectivity strength in
PT neonates. These findings are discussed in the light of perinatal brain
developmental trajectories and deepen our understanding atypical AVI abilities in
PT infants. More generally, the present work contributes to our understanding of
whole-brain network development by investigating functional-structural coupling
from a network neuroscience perspective.