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2025 ; 23
(1
): 104
Nephropedia Template TP
gab.com Text
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English Wikipedia
Validation of the health-related quality of life instrument with 8 items for
assessing health-related quality of life in patients with oropharyngeal cancer: a
comparison with the EQ-5D-5L
#MMPMID41102677
Hong GU
; Koo BS
; Kim MJ
; Sim WJ
; Lee AY
; An JE
; Yu SY
; Lee SY
; Lee SH
Health Qual Life Outcomes
2025[Oct]; 23
(1
): 104
PMID41102677
show ga
BACKGROUND: To overcome the limitations of existing health-related quality of
life (HRQoL) instruments, the HRQoL Instrument with 8 Items (HINT-8) was
developed for the Korean population. We aimed to evaluate the validity,
interrater reliability, and agreement of the HINT-8 compared to the EQ-5D-5 L
among patients with oropharyngeal cancer (OPC). METHODS: A total of 327 patients
with OPC aged???19 years who received treatment at 14 hospitals in South Korea
were recruited between August 2023 and February 2024. HRQoL was assessed using
the two instruments. The psychometric evaluation included analyses of validity
(convergent and known-group validity), agreement (intraclass correlation
coefficient and Bland-Altman analysis), and reliability (internal consistency
measured by Cronbach's alpha). The ceiling effects and score distributions were
also examined. RESULTS: In total, 299 respondents were included in the final
analysis. Both instruments demonstrated high internal consistency (HINT-8:
??=?0.872; EQ-5D-5 L: ??=?0.845) and good agreement (intraclass correlation
coefficient [ICC]?=?0.80; 95% confidence interval [CI]: 0.76-0.84). The
convergent validity was supported by strong correlations between the HINT-8 index
and both the EQ-5D-5 L index (r?=?0.805) and EQ VAS (r?=?0.715). The ceiling
effect of HINT-8 (12.7%) was substantially lower than the EQ-5D-5 L (32.8%).
CONCLUSIONS: The HINT-8 is a valid, reliable, and responsive instrument for
measuring HRQoL in patients with oropharyngeal cancer. These findings suggest
that HINT-8 can serve as a valuable complementary instrument to the EQ-5D-5 L.