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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2025 ; 15
(1
): 36255
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Association of serum zinc concentration with multiple surrogates of insulin
resistance in a population-based study
#MMPMID41102311
Ghafouri-Taleghani F
; Bahadoran Z
; Jeddi S
; Tohidi M
; Azizi F
Sci Rep
2025[Oct]; 15
(1
): 36255
PMID41102311
show ga
The global prevalence of insulin resistance is increasing and it plays a
significant role in the pathophysiology of chronic non-communicable diseases.
Lipid metabolism disorder is a key mediator of insulin resistance. This
cross-sectional study investigated the possible association between serum zinc
(SZn) concentration and distinct surrogates of insulin resistance (IR). SZn were
measured using flame atomic absorption spectrometry (FAAS) in 3078 adults (mean
age of 48.8?±?14.5, and 39.8% were male) participated in the Tehran Lipid and
Glucose Study (2009-2011). The associations between SZn concentrations and
surrogates of IR including homeostasis model assessment of insulin resistance
(HOMA-IR), the triglyceride-glucose (TyG) index, the TyG-body mass index (TyG-BMI
index), the metabolic score for insulin resistance (METS-IR), and the
triglyceride-to-high-density lipoprotein cholesterol ratio (TG-to-HDL-C ratio),
were assessed using multivariable logistic regression analysis. The mean serum
zinc concentration was 112?±?37.1 µg/dL. Serum zinc concentrations exceeding
119 µg/dL were significantly associated with a 32% increased probability of IR,
identified by elevated TyG index (OR?=?1.32; 95% CI?=?1.08-1.59). Similarly, SZn
concentrations greater than 91.3 µg/dL and 119 µg/dL were associated with a 30%
and 34% increased probability of IR, as identified by the TG-HDL-C ratio,
respectively. Our study revealed that elevated SZn concentrations, probably due
to exposure to environmental pollutants, may be associated with increased
probability of IR, identified by the high TyG index and TG-to-HDL-C ratio.