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10.1038/s41419-025-08074-1 http://scihub22266oqcxt.onion/10.1038/s41419-025-08074-1 C12533068!12533068 !41102183     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41102183 &cmd=llinks): Failed to open stream: HTTP request failed! 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The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma |pdf=|usr=}}{{41102183 }} gab.com Text The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=41102183 #FOAvip Elevated activity of proto-oncogene tyrosine kinase Src is associated with tumorigenesis and progression of hepatocellular carcinoma (HCC). It is well recognized that activation of Src is mainly driven by its intermolecular autophosphorylation. However, the precise mechanism involved in the activation of Src remains to be fully understood. Here we identified tripartite motif-containing protein (TRIM) 56, a member of E3 ubiquitin ligase family, as a novel regulator of Src activation. The data revealed that TRIM56 directly interacted with Src and catalyzed the polyubiquitination and subsequent aggregation of Src, resulting in Src activation and HCC progression. Mechanistically, TRIM56 interacted with the SH3 domain of Src protein via its B-box1 domain and catalyzed the Lys63-linked polyubiquitination of Src at the Lys184 residue, leading to the aggregation and activation of Src. Altogether, here we demonstrated that TRIM56 acted as a tumor promoter in HCC and it exerted a novel regulatory effect on Src activation. Thus, this study suggested a promising therapeutic strategy for HCC patients by targeting TRIM56. Twit Text FOAVip The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=41102183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41102183 #FOAvip English Wikipedia <ref>{{Cite pmid|41102183 }}</ref> The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma #MMPMID41102183 Zhu L ; Cui X ; Xu H ; Yang M ; Han L Cell Death Dis 2025[Oct]; 16 (1 ): 731 PMID41102183 show ga Elevated activity of proto-oncogene tyrosine kinase Src is associated with tumorigenesis and progression of hepatocellular carcinoma (HCC). It is well recognized that activation of Src is mainly driven by its intermolecular autophosphorylation. However, the precise mechanism involved in the activation of Src remains to be fully understood. Here we identified tripartite motif-containing protein (TRIM) 56, a member of E3 ubiquitin ligase family, as a novel regulator of Src activation. The data revealed that TRIM56 directly interacted with Src and catalyzed the polyubiquitination and subsequent aggregation of Src, resulting in Src activation and HCC progression. Mechanistically, TRIM56 interacted with the SH3 domain of Src protein via its B-box1 domain and catalyzed the Lys63-linked polyubiquitination of Src at the Lys184 residue, leading to the aggregation and activation of Src. Altogether, here we demonstrated that TRIM56 acted as a tumor promoter in HCC and it exerted a novel regulatory effect on Src activation. Thus, this study suggested a promising therapeutic strategy for HCC patients by targeting TRIM56. |*Carcinoma, Hepatocellular/pathology/genetics/metabolism/enzymology [MESH] |*Liver Neoplasms/pathology/genetics/metabolism/enzymology [MESH] |*Lysine/metabolism [MESH] |*Tripartite Motif Proteins/metabolism/genetics [MESH] |*Ubiquitin-Protein Ligases/metabolism/genetics [MESH] |*src-Family Kinases/metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Protein Binding [MESH] |Proto-Oncogene Mas [MESH]The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of (epmc).pdf DeepDyve Pubget Overpricing