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2025 ; 5
(1
): 427
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English Wikipedia
Angiotensin receptor-neprilysin inhibitor treatment in people with chronic
obstructive pulmonary disease and heart failure
#MMPMID41102262
Hsu WH
; Shiau BW
; Wu JY
; Chuang MH
; Tsai YW
; Huang PY
; Hu KC
; Hsu W
; Liu TH
; Liao KM
; Lai CC
Commun Med (Lond)
2025[Oct]; 5
(1
): 427
PMID41102262
show ga
BACKGROUND: While renin-angiotensin system inhibitors (RASi) have shown benefits
for people with both heart failure (HF) and chronic obstructive pulmonary disease
(COPD), limited data exists on the use of angiotensin receptor-neprilysin
inhibitors (ARNIs) in this population. This study compares the effectiveness of
RASi and ARNIs in people with coexisting COPD and HF. METHODS: We identified
individuals who started treatment with either ARNI or RASi since August 1, 2015.
We assessed outcomes such as COPD exacerbations, acute respiratory failure, and
lower respiratory tract infections (LRTIs) over 30 days to 3 years. Kaplan-Meier
survival analysis and Cox regression models were applied to estimate survival
probabilities and hazard ratios (HR). RESULTS: Among 9,071 ARNI users and 71,836
RASi users, the ARNI group has fewer respiratory complications. The ARNI group
has a higher proportion of females compared to the RASi group (38.2% vs. 31.5%).
Specifically, ARNI users have a lower incidence of COPD exacerbations (13.1% vs.
18.7%; HR, 0.84), acute respiratory failure (16.2% vs. 22.0%; HR, 0.90), and
LRTIs (16.9% vs. 22.9%; HR, 0.91). CONCLUSIONS: In people with both COPD and HF,
ARNI treatment is associated with fewer respiratory complications compared to
RASi.
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