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10.1038/s41398-025-03650-7 http://scihub22266oqcxt.onion/10.1038/s41398-025-03650-7 C12532823!12532823 !41102170     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41102170 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transl+Psychiatry 2025 ; 15 (1 ): 403 Nephropedia Template TP {{tp|p=41102170 |t=2025. Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity |pdf=|usr=}}{{41102170 }} gab.com Text Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity JO: Transl Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=41102170 #FOAvip Traumatic brain injury (TBI) is a global health challenge that substantially contributes to disability and is responsible for 30% of injury-related deaths. Annually, over 50 million TBIs occur worldwide, with many adult TBI patients in emergency departments presenting with alcohol in their system. TBI is also a known risk factor for alcohol abuse, yet its interaction with alcohol consumption remains poorly understood. In this study, we demonstrate that the fluid percussion injury (FPI) model of TBI in male C57BL/6 mice significantly increases alcohol consumption and impairs cognitive function. FPI markedly reduced the number and activity of striatal cholinergic interneurons (CINs) while increasing striatal microglial cells. Notably, depleting microglial cells by systemic PLX 5622 administration enhanced cholinergic activity, as measured by electrophysiology and acetylcholine biosensing. These findings suggest that TBI promotes alcohol consumption and impairs cognitive abilities through microglia activation and reduced cholinergic function. This research provides critical insight into the mechanisms linking TBI with increased alcohol use and cognitive deficits, potentially guiding future therapeutic strategies. Twit Text FOAVip Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity ????Transl Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=41102170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41102170 #FOAvip English Wikipedia <ref>{{Cite pmid|41102170 }}</ref> Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity #MMPMID41102170 Gangal H ; Iannucci J ; Huang Y ; Chen R ; Purvines W ; Davis WT ; Rivera A ; Johnson G ; Xie X ; Mukherjee S ; Vierkant V ; Mims K ; O'Neill K ; Wang X ; Shapiro LA ; Wang J Transl Psychiatry 2025[Oct]; 15 (1 ): 403 PMID41102170 show ga Traumatic brain injury (TBI) is a global health challenge that substantially contributes to disability and is responsible for 30% of injury-related deaths. Annually, over 50 million TBIs occur worldwide, with many adult TBI patients in emergency departments presenting with alcohol in their system. TBI is also a known risk factor for alcohol abuse, yet its interaction with alcohol consumption remains poorly understood. In this study, we demonstrate that the fluid percussion injury (FPI) model of TBI in male C57BL/6 mice significantly increases alcohol consumption and impairs cognitive function. FPI markedly reduced the number and activity of striatal cholinergic interneurons (CINs) while increasing striatal microglial cells. Notably, depleting microglial cells by systemic PLX 5622 administration enhanced cholinergic activity, as measured by electrophysiology and acetylcholine biosensing. These findings suggest that TBI promotes alcohol consumption and impairs cognitive abilities through microglia activation and reduced cholinergic function. This research provides critical insight into the mechanisms linking TBI with increased alcohol use and cognitive deficits, potentially guiding future therapeutic strategies. |*Alcohol Drinking/physiopathology [MESH] |*Brain Injuries, Traumatic/complications/physiopathology [MESH] |*Cholinergic Neurons/metabolism [MESH] |*Cognitive Dysfunction/etiology/physiopathology [MESH] |*Neuroinflammatory Diseases/physiopathology [MESH] |Acetylcholine/metabolism [MESH] |Animals [MESH] |Corpus Striatum [MESH] |Disease Models, Animal [MESH] |Interneurons [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]Traumatic brain injury exacerbates alcohol consumption and neuroinflam(epmc).pdf DeepDyve Pubget Overpricing