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10.1093/stcltm/szaf045 http://scihub22266oqcxt.onion/10.1093/stcltm/szaf045 C12530881!12530881 !41101946     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41101946 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cells+Transl+Med 2025 ; 14 (10 ): ä Nephropedia Template TP {{tp|p=41101946 |t=2025. iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h  iIL1?hi macrophage |pdf=|usr=}}{{41101946 }} gab.com Text iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h  iIL1 hi macrophage JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=41101946 #FOAvip BACKGROUND: Joint bone destruction in rheumatoid arthritis (RA) leads to poor prognosis, with current treatments mainly targeting inflammation and limited focus on bone damage. Mesenchymal stem cells (MSCs) offer anti-inflammatory and bone repair properties, but their clinical application is hindered by cellular heterogeneity. Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) present a promising alternative due to their lower heterogeneity and replicative senescence, although their potential in RA treatment remains underexplored. METHODS: iMSCs were injected intraarticularly in a collagen-induced arthritis (CIA) model. Treatment outcomes, including plantar swelling, joint score, histological and immunohistochemical staining, microCT imaging, and bone loss, were assessed. Single-cell RNA sequencing was employed to study iMSCs' effects on synovial macrophage subsets. RESULTS: In vivo, iMSCs significantly reduced systemic inflammation and joint bone damage. Analysis of macrophage subpopulations revealed that iMSCs shifted macrophages from a pro-inflammatory CD86hiIL1?hi cluster to an anti-inflammatory CD86hiIL1?lo cluster, leading to reduced inflammation and bone resorption. CONCLUSIONS: iMSCs effectively alleviate inflammation and bone damage in CIA by modulating macrophage phenotypes, demonstrating potential for RA therapy. Twit Text FOAVip iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h  iIL1 hi macrophage ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=41101946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41101946 #FOAvip English Wikipedia <ref>{{Cite pmid|41101946 }}</ref> iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h  iIL1?hi macrophage #MMPMID41101946 Wu Z ; Su Y ; Li J ; Liu X ; Liu Y ; Zhao L ; Li L ; Gao C ; Yao M ; Zhang L Stem Cells Transl Med 2025[Sep]; 14 (10 ): ä PMID41101946 show ga BACKGROUND: Joint bone destruction in rheumatoid arthritis (RA) leads to poor prognosis, with current treatments mainly targeting inflammation and limited focus on bone damage. Mesenchymal stem cells (MSCs) offer anti-inflammatory and bone repair properties, but their clinical application is hindered by cellular heterogeneity. Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) present a promising alternative due to their lower heterogeneity and replicative senescence, although their potential in RA treatment remains underexplored. METHODS: iMSCs were injected intraarticularly in a collagen-induced arthritis (CIA) model. Treatment outcomes, including plantar swelling, joint score, histological and immunohistochemical staining, microCT imaging, and bone loss, were assessed. Single-cell RNA sequencing was employed to study iMSCs' effects on synovial macrophage subsets. RESULTS: In vivo, iMSCs significantly reduced systemic inflammation and joint bone damage. Analysis of macrophage subpopulations revealed that iMSCs shifted macrophages from a pro-inflammatory CD86hiIL1?hi cluster to an anti-inflammatory CD86hiIL1?lo cluster, leading to reduced inflammation and bone resorption. CONCLUSIONS: iMSCs effectively alleviate inflammation and bone damage in CIA by modulating macrophage phenotypes, demonstrating potential for RA therapy. |*Arthritis, Experimental/therapy/pathology [MESH] |*B7-2 Antigen/metabolism [MESH] |*Induced Pluripotent Stem Cells/cytology/metabolism [MESH] |*Macrophages/metabolism [MESH] |*Mesenchymal Stem Cell Transplantation/methods [MESH] |*Mesenchymal Stem Cells/cytology/metabolism [MESH] |*Synovial Membrane/pathology [MESH] |Animals [MESH] |Arthritis, Rheumatoid/therapy [MESH] |Male [MESH]iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mi(epmc).pdf DeepDyve Pubget Overpricing