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10.1136/rmdopen-2025-005787 http://scihub22266oqcxt.onion/10.1136/rmdopen-2025-005787 C12530366!12530366 !41101787     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41101787 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       RMD+Open 2025 ; 11 (4 ): ä Nephropedia Template TP {{tp|p=41101787 |t=2025. Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis |pdf=|usr=}}{{41101787 }} gab.com Text Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis JO: RMD Open http://www.kidney.de/pget.php?&tw=1&pmid=41101787 #FOAvip OBJECTIVES: To evaluate the clinical applicability of autoantibodies (AAbs) measured by ELISA against the angiotensin II type 1 receptor (AT(1)R) and endothelin-1 type A receptor (ET(A)R) in systemic sclerosis (SSc) patients. METHODS: Serum samples from n=279?SSc patients from the Leiden Systemic Sclerosis cohort, n=42 patients with primary Raynaud's phenomenon, n=24 patients with rheumatoid arthritis and n=20 healthy controls were tested for anti-AT(1)R- and anti-ET(A)R AAbs. Levels were compared between groups with Mann-Whitney U tests or Kruskal-Wallis tests. Risk ratios and Kaplan-Meier analyses were used to determine associations between AAbs and disease manifestations or all-cause mortality. Analyses were repeated in an independent cohort with n=310?SSc patients from the Radboud University Medical Center. RESULTS: AAbs against AT(1)R and ET(A)R could be detected by ELISA in the sera of all groups tested. Levels were slightly higher in the SSc group compared with the pooled non-SSc group (p=0.043). No associations could be found between anti-AT(1)R AAbs or anti-ET(A)R AAbs and disease manifestations or all-cause mortality. In the Radboud cohort, patients with diffuse cutaneous SSc (p=0.001) and interstitial lung disease (p=0.007) had higher median anti-ET(A)R AAb levels. Patients who died during follow-up had lower levels of anti-AT(1)R- (p=0.005) and anti-ET(A)R AAbs (p=0.020). CONCLUSIONS: We confirm positive ELISAs for anti-AT(1)R AAbs and anti-ET(A)R AAbs in the sera of several patient groups and healthy controls. Previously described associations with disease manifestations and all-cause mortality could not be confirmed in our cohorts. Based on the current study, the determination of these AAbs is of limited predictive value in clinical practice. Twit Text FOAVip Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis ????RMD Open http://www.kidney.de/pget.php?&tw=1&pmid=41101787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41101787 #FOAvip English Wikipedia <ref>{{Cite pmid|41101787 }}</ref> Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis #MMPMID41101787 van der Wouden KE ; Ahmed S ; van Oostveen WM ; Hoekstra EM ; Liem SIE ; Huizinga TWJ ; Toes REM ; Voskuyl AE ; Riemekasten G ; Fehres CM ; Vonk M ; de Vries-Bouwstra JK RMD Open 2025[Oct]; 11 (4 ): ä PMID41101787 show ga OBJECTIVES: To evaluate the clinical applicability of autoantibodies (AAbs) measured by ELISA against the angiotensin II type 1 receptor (AT(1)R) and endothelin-1 type A receptor (ET(A)R) in systemic sclerosis (SSc) patients. METHODS: Serum samples from n=279?SSc patients from the Leiden Systemic Sclerosis cohort, n=42 patients with primary Raynaud's phenomenon, n=24 patients with rheumatoid arthritis and n=20 healthy controls were tested for anti-AT(1)R- and anti-ET(A)R AAbs. Levels were compared between groups with Mann-Whitney U tests or Kruskal-Wallis tests. Risk ratios and Kaplan-Meier analyses were used to determine associations between AAbs and disease manifestations or all-cause mortality. Analyses were repeated in an independent cohort with n=310?SSc patients from the Radboud University Medical Center. RESULTS: AAbs against AT(1)R and ET(A)R could be detected by ELISA in the sera of all groups tested. Levels were slightly higher in the SSc group compared with the pooled non-SSc group (p=0.043). No associations could be found between anti-AT(1)R AAbs or anti-ET(A)R AAbs and disease manifestations or all-cause mortality. In the Radboud cohort, patients with diffuse cutaneous SSc (p=0.001) and interstitial lung disease (p=0.007) had higher median anti-ET(A)R AAb levels. Patients who died during follow-up had lower levels of anti-AT(1)R- (p=0.005) and anti-ET(A)R AAbs (p=0.020). CONCLUSIONS: We confirm positive ELISAs for anti-AT(1)R AAbs and anti-ET(A)R AAbs in the sera of several patient groups and healthy controls. Previously described associations with disease manifestations and all-cause mortality could not be confirmed in our cohorts. Based on the current study, the determination of these AAbs is of limited predictive value in clinical practice. |*Autoantibodies/blood/immunology [MESH] |*Receptor, Angiotensin, Type 1/immunology [MESH] |*Receptor, Endothelin A/immunology [MESH] |*Scleroderma, Systemic/immunology/mortality/blood/diagnosis [MESH] |Adult [MESH] |Aged [MESH] |Biomarkers/blood [MESH] |Case-Control Studies [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Humans [MESH] |Male [MESH]Autoantibodies directed against the angiotensin II type 1 receptor and(epmc).pdf DeepDyve Pubget Overpricing