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2025 ; 19
(9
): e70148
Nephropedia Template TP
gab.com Text
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English Wikipedia
Economic Burden of Respiratory Viruses in Latin America and the Caribbean (LAC):
A Scoping Literature Review
#MMPMID40908027
Alvis-Zakzuk NJ
; Couto P
; Jara JH
; Descalzo M
; Rondy M
; Tempia S
; Vicari A
Influenza Other Respir Viruses
2025[Sep]; 19
(9
): e70148
PMID40908027
show ga
OBJECTIVE: The objective of this study is to summarize the state of knowledge on
the economic burden and cost of illness due to influenza, SARS-CoV-2, respiratory
syncytial virus (RSV), and other respiratory viruses (ORV) in Latin America and
the Caribbean (LAC). METHODS: We performed a scoping review across three
databases (PubMed-Medline, Scielo, and Embase) without time restriction,
including economic burden and cost-of-illness studies. We extracted and analyzed
data on publication year, population, study type, perspective, costing
techniques, and settings. We reported absolute and relative frequencies to
summarize the results. Economic burden estimates were divided by the gross
domestic product (GDP) for each country. Costs were converted into 2022
international dollars (PPP). RESULTS: Overall, 2638 articles were retrieved; we
included 44 full texts from 16 LAC countries. Twenty-four (54.5%) studies focused
on influenza, 16 (36.4%) on SARS-CoV-2, 3 (6.8%) on RSV, and 1 on ORV. Twenty two
(50.0%) focused on cost-effectiveness (related to vaccination)/cost-benefit
analysis, and 17 (38.6%) focused on cost of illness. Most studies (n?=?33, 75.0%)
were conducted from the third-party perspective. Fifty percent of the studies
used a bottom-up costing technique and 29.6% top-down. Influenza direct medical
costs ranged from I$6.6-I$300.3 for outpatients and I$62.8-I$222,920 for
inpatients; for RSV from I$68.3-I$1292; and for SARS-CoV-2 between I$69.9 and
I$38,039. The total annual costs of the influenza economic burden ranged between
0.0003% and 1.33% of the GDP. CONCLUSION: This study showed variability in
costing methods, perspectives, and types of studies among LAC countries. This
variability underscores the need for standardized methodologies in future cost
studies to ensure comparability and reliability of results.