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10.1097/TXD.0000000000001827 http://scihub22266oqcxt.onion/10.1097/TXD.0000000000001827 C12208634!12208634 !40590005     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=40590005 &cmd=llinks): Failed to open stream: HTTP request failed! 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Outcomes of High Kidney Donor Profile Index Hepatitis C Nucleic Acid Testing Positive Kidneys are Equivalent to Matched Hepatitis C Nucleic Acid Testing Negative Kidneys |pdf=|usr=}}{{40590005 }} gab.com Text Outcomes of High Kidney Donor Profile Index Hepatitis C Nucleic Acid Testing Positive Kidneys are Equivalent to Matched Hepatitis C Nucleic Acid Testing Negative Kidneys JO: Transplant Direct http://www.kidney.de/pget.php?&tw=1&pmid=40590005 #FOAvip BACKGROUND: A recent Organ Procurement and Transplant Network policy change removes hepatitis C virus (HCV) status and race from the Kidney Donor Profile Index (KDPI) calculation, thereby lowering the KDPI of HCV nucleic acid testing positive (NAT(+)) kidneys and increasing their allocation priority. However, even in the era of direct-acting antivirals, high KDPI HCV NAT(+) kidneys exhibited higher discard rates compared with their HCV NAT(-) counterparts, and outcome data for this "high-risk" group remain limited. This study aims to address this knowledge gap by providing comprehensive outcome data to better inform organ allocation and selection decisions under the new KDPI framework. METHODS: Using national transplant data from 2015 to 2023, we analyzed adult deceased donor kidney transplants stratified by KDPI and HCV NAT status. An exact matching model was used to identify the matched HCV NAT(-) group. RESULTS: No significant differences were observed in delayed graft function, rejection, or patient and graft survival between high KDPI HCV NAT(+) and matched HCV NAT(-) recipients. High KDPI HCV NAT(+) kidneys were more often allocated regionally or nationally, with 67.6% occurring in 4 regions. Their recipients were more likely to have a high school education and shorter wait times. After the policy change, >90% of prior high KDPI HCV NAT(+) kidneys will no longer be classified as high KDPI. CONCLUSIONS: Our findings support the safe utilization of previously high KDPI HCV NAT(+) kidneys after a policy change. Although the revised KDPI may assist clinicians in identifying higher-quality organs, its impact on existing sociodemographic disparities and overall organ utilization rate remains uncertain. Twit Text FOAVip Outcomes of High Kidney Donor Profile Index Hepatitis C Nucleic Acid Testing Positive Kidneys are Equivalent to Matched Hepatitis C Nucleic Acid Testing Negative Kidneys ????Transplant Direct http://www.kidney.de/pget.php?&tw=1&pmid=40590005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40590005 #FOAvip English Wikipedia <ref>{{Cite pmid|40590005 }}</ref> Outcomes of High Kidney Donor Profile Index Hepatitis C Nucleic Acid Testing Positive Kidneys are Equivalent to Matched Hepatitis C Nucleic Acid Testing Negative Kidneys #MMPMID40590005 He S ; Thomas CP ; Gunderson AE ; Ten Eyck P ; Reed AI Transplant Direct 2025[Jul]; 11 (7 ): e1827 PMID40590005 show ga BACKGROUND: A recent Organ Procurement and Transplant Network policy change removes hepatitis C virus (HCV) status and race from the Kidney Donor Profile Index (KDPI) calculation, thereby lowering the KDPI of HCV nucleic acid testing positive (NAT(+)) kidneys and increasing their allocation priority. However, even in the era of direct-acting antivirals, high KDPI HCV NAT(+) kidneys exhibited higher discard rates compared with their HCV NAT(-) counterparts, and outcome data for this "high-risk" group remain limited. This study aims to address this knowledge gap by providing comprehensive outcome data to better inform organ allocation and selection decisions under the new KDPI framework. METHODS: Using national transplant data from 2015 to 2023, we analyzed adult deceased donor kidney transplants stratified by KDPI and HCV NAT status. An exact matching model was used to identify the matched HCV NAT(-) group. RESULTS: No significant differences were observed in delayed graft function, rejection, or patient and graft survival between high KDPI HCV NAT(+) and matched HCV NAT(-) recipients. High KDPI HCV NAT(+) kidneys were more often allocated regionally or nationally, with 67.6% occurring in 4 regions. Their recipients were more likely to have a high school education and shorter wait times. After the policy change, >90% of prior high KDPI HCV NAT(+) kidneys will no longer be classified as high KDPI. CONCLUSIONS: Our findings support the safe utilization of previously high KDPI HCV NAT(+) kidneys after a policy change. Although the revised KDPI may assist clinicians in identifying higher-quality organs, its impact on existing sociodemographic disparities and overall organ utilization rate remains uncertain. äOutcomes of High Kidney Donor Profile Index Hepatitis C Nucleic Acid T(epmc).pdf DeepDyve Pubget Overpricing