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2025 ; 18
(ä): 741-746
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English Wikipedia
Full-Thickness Macular Hole Formation After Intravitreal Faricimab Injection for
Polypoidal Choroidal Vasculopathy
#MMPMID40585966
Tavonvunchai F
; Chanwimol K
Int Med Case Rep J
2025[]; 18
(ä): 741-746
PMID40585966
show ga
PURPOSE: To report a case of an Asian man with idiopathic polypoidal choroidal
vasculopathy (PCV) who developed a full-thickness macular hole (FTMH) following
treatment with intravitreal faricimab, which resolved after vitreoretinal
surgery. PATIENTS AND METHODS: A 63-year-old man with idiopathic PCV was treated
with intravitreal faricimab. Although pigment epithelial detachment (PED)
decreased, he developed cystoid macular edema with vitreomacular traction (VMT),
which progressed to a FTMH. RESULTS: Pars plana vitrectomy and internal limiting
membrane peeling successfully treated the FTMH. One year after the procedure, the
macular hole remains closed, and the PCV was inactive. CONCLUSION: Various
mechanisms may have contributed to the exacerbation of the preexisting VMT and
PED, which finally resulted in the development of a FTMH. Careful attention
should be paid to changes in the vitreomacular interface and posterior vitreous
detachment before performing intravitreal anti-vascular endothelial growth factor
treatment. Nevertheless, FTMHs can be successfully treated with prompt
vitreoretinal surgery.