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2025 ; 13
(7
): e70522
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Yak (Bos grunniens) Meat Peptides: Effects on Immunity, Hypoxia Tolerance, and
Antioxidant Capacity in Hypotonic Hypoxia Mice
#MMPMID40585494
Zhao G
; Zhang Y
; Wang K
; Xu L
; Yin M
; Kong X
; Zhu C
Food Sci Nutr
2025[Jul]; 13
(7
): e70522
PMID40585494
show ga
The present study focused on the investigation of yak (Bos grunniens) meat
peptides on immunity, antioxidant capacity, and hypoxia tolerance in hypotonic
hypoxic mice using malondialdehyde (MDA), superoxide dismutase (SOD) kit, and so
on. Yak protein powder was extracted first, and then peptides were obtained by
INFOGEST static simulation of human gastrointestinal tract digestion. The results
demonstrated that yak meat peptides increased the content of immune cells, oxygen
transport capacity, and antioxidant enzyme activities in mice, while reducing
oxidative stress damage in the body. In addition, protein expression of
hypoxia-related genes hypoxia-inducible factor (HIF) and erythropoietin (EPO) was
improved. This study can provide a theoretical foundation for reducing the harm
of reactive oxygen species and free radicals to the human body and for the
development and utilization of yak bioactive substances.