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2025 ; 17
(ä): 375-401
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Targeting Molecular Pathways in Breast Cancer Using Plant-Derived Bioactive
Compounds: A Comprehensive Review
#MMPMID40585862
Al Khalily IA
; Megantara S
; Aulifa DL
J Exp Pharmacol
2025[]; 17
(ä): 375-401
PMID40585862
show ga
Breast cancer remains one of the most prevalent and life-threatening diseases
worldwide, affecting millions of individuals and their families. While current
treatments such as chemotherapy, radiation, and targeted therapies have improved
survival rates, they often come with severe side effects and limitations. This
has led to a growing interest in natural compounds derived from medicinal plants
as safer and potentially more effective alternatives. These plant-based compounds
have shown promise in targeting key cancer pathways, including EGFR,
PI3K/AKT/mTOR, NF-?B, JAK-STAT3, RAF/MEK/ERK, BCL-2, p53, and SKP/p21, helping to
inhibit tumor growth, induce cancer cell death, and prevent metastasis. Research
combining computational, in vitro, and in vivo studies has revealed that
bioactive compounds such as flavonoids, alkaloids, and phenolics can provide
meaningful therapeutic benefits. However, challenges such as ensuring proper
absorption, stability, and clinical application remain. By addressing these
limitations through advanced drug formulations and integration into existing
treatment plans, plant-based therapies could play a vital role in improving
outcomes for breast cancer patients. This review sheds light on the potential of
natural compounds to offer hope for more effective and less harmful cancer
treatments in the future.