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10.12688/f1000research.144067.2 http://scihub22266oqcxt.onion/10.12688/f1000research.144067.2 C12203043!12203043 !40585879     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=40585879 &cmd=llinks): Failed to open stream: HTTP request failed! 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Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action |pdf=|usr=}}{{40585879 }} gab.com Text Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=40585879 #FOAvip Pain and inflammation are the consequences of sore throat, dental and oral procedures, infections, ulcers and head and neck chemotherapy/radiotherapy, and their management is of fundamental importance to avoid distress in patients. Benzydamine hydrochloride (HCl) is a topical indolic nonsteroidal anti-inflammatory drug, endowed with analgesic and anesthetic activity, and with antimicrobial (including both gram-positive and gram-negative bacteria) and antifungal properties (targeting Candida albicans and non-albicans strains), used in odontostomatology, otorhinolaryngology, and gynecology for its properties. This molecule has a lipophilic nature, showing high affinity with cell membranes and exhibiting membrane stabilization properties, resulting in local anesthesia, an effect related also to the interaction of the drug with cationic channels. Unlike other non-steroidal anti-inflammatory drugs, benzydamine HCl is a weak inhibitor of cyclooxygenase or lipoxygenase and consequently its primary mechanisms of action are not related to arachidonic acid metabolism and do not affect the biosynthesis of the inflammation mediators prostanoids, prostacyclin, thromboxane and leukotrienes. Benzydamine HCl is able to inhibit the production of pro-inflammatory cytokines, with consequent analgesia. Moreover, benzydamine HCl is able to inhibit leukocyte-endothelial interactions and platelet aggregation. Here we review the most updated clinical data available on benzydamine HCl local application as spray, mouthwash or gargling and evidence of its effectiveness in inflammatory and/or septic conditions in the otorhinolaryngology and odontostomatology settings, with particular reference to sore throat, oral inflammation, dental plaque, tonsillitis/tonsillectomy and chemo- or radiotherapy-induced oral mucositis. Novel formulations for oral and oromucosal/buccal/intraoral administration of benzydamine HCl are also reviewed, including in situ gelling formulations to be sprayed onto the damaged oral mucosa. Finally, novel data on the potential role of benzydamine HCl in nociceptor excitability are introduced. Twit Text FOAVip Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=40585879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40585879 #FOAvip English Wikipedia <ref>{{Cite pmid|40585879 }}</ref> Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action #MMPMID40585879 Ferrer-Montiel A F1000Res 2024[]; 13 (ä): 350 PMID40585879 show ga Pain and inflammation are the consequences of sore throat, dental and oral procedures, infections, ulcers and head and neck chemotherapy/radiotherapy, and their management is of fundamental importance to avoid distress in patients. Benzydamine hydrochloride (HCl) is a topical indolic nonsteroidal anti-inflammatory drug, endowed with analgesic and anesthetic activity, and with antimicrobial (including both gram-positive and gram-negative bacteria) and antifungal properties (targeting Candida albicans and non-albicans strains), used in odontostomatology, otorhinolaryngology, and gynecology for its properties. This molecule has a lipophilic nature, showing high affinity with cell membranes and exhibiting membrane stabilization properties, resulting in local anesthesia, an effect related also to the interaction of the drug with cationic channels. Unlike other non-steroidal anti-inflammatory drugs, benzydamine HCl is a weak inhibitor of cyclooxygenase or lipoxygenase and consequently its primary mechanisms of action are not related to arachidonic acid metabolism and do not affect the biosynthesis of the inflammation mediators prostanoids, prostacyclin, thromboxane and leukotrienes. Benzydamine HCl is able to inhibit the production of pro-inflammatory cytokines, with consequent analgesia. Moreover, benzydamine HCl is able to inhibit leukocyte-endothelial interactions and platelet aggregation. Here we review the most updated clinical data available on benzydamine HCl local application as spray, mouthwash or gargling and evidence of its effectiveness in inflammatory and/or septic conditions in the otorhinolaryngology and odontostomatology settings, with particular reference to sore throat, oral inflammation, dental plaque, tonsillitis/tonsillectomy and chemo- or radiotherapy-induced oral mucositis. Novel formulations for oral and oromucosal/buccal/intraoral administration of benzydamine HCl are also reviewed, including in situ gelling formulations to be sprayed onto the damaged oral mucosa. Finally, novel data on the potential role of benzydamine HCl in nociceptor excitability are introduced. |*Anti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic use [MESH] |*Benzydamine/pharmacology/therapeutic use/chemistry [MESH] |Animals [MESH]Benzydamine hydrochloride: an overview on a well-established drug with(epmc).pdf DeepDyve Pubget Overpricing