Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1177/17588359251351449 http://scihub22266oqcxt.onion/10.1177/17588359251351449 C12202949!12202949 !40585875     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40585875 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ther+Adv+Med+Oncol 2025 ; 17 (ä): 17588359251351449 Nephropedia Template TP {{tp|p=40585875 |t=2025. Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study) |pdf=|usr=}}{{40585875 }} gab.com Text Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study) JO: Ther Adv Med Oncol http://www.kidney.de/pget.php?&tw=1&pmid=40585875 #FOAvip BACKGROUND: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile. OBJECTIVES: This study aims to explore the potential correlation between estimated indoor radon concentrations and the frequency of driver alterations in NSCLC across Europe. DESIGN: Ecological study of European countries with available data on indoor radon exposure (estimated mean levels and the proportion (%) of dwellings with concentrations >200 and >400?Bq/m(3)), and frequency of NSCLC actionable genomic alterations (EGFR, ALK) from PubMed articles and meeting abstracts with sample size >100 patients. METHODS: We retrospectively analyzed NSCLC molecular data and radon exposure levels from European countries. Radon data, including the mean and proportion (%) of dwellings with concentrations >200 and >400?Bq/m(3), were sourced from the European Commission Report 2005. NSCLC molecular alteration frequency (EGFR, ALK) was extracted from PubMed articles with sample sizes >100 patients. The correlation between molecular alteration frequencies and country-specific radon data were assessed. RESULTS: Data on radon exposure and EGFR/ALK frequency were available for 21 European countries. Five countries had mean radon levels >100?Bq/m(3), and eight countries had ?3% of dwellings with concentrations >400?Bq/m(3). The median frequency of EGFR mutations and ALK fusions was 11.3% (range 7%-18.1%) and 4.1% (range 3.4%-12%), respectively. A positive correlation was found between estimated ALK-fusion frequency and the percentage of dwellings with >400?Bq/m(3) (r?=?0.72, p?=?0.001). No correlation was found between EGFR mutation frequency and radon exposure. CONCLUSION: We found a positive correlation between estimated ALK fusion frequency in NSCLC and the proportion of dwellings exceeding 400?Bq/m(3) radon exposure in 21 European countries. Further research is needed to explore the potential influence of radon and other environmental factors on NSCLC with driver alterations. Twit Text FOAVip Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study) ????Ther Adv Med Oncol http://www.kidney.de/pget.php?&tw=1&pmid=40585875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40585875 #FOAvip English Wikipedia <ref>{{Cite pmid|40585875 }}</ref> Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study) #MMPMID40585875 García-Pardo M ; García de Herreros M ; Auclin E ; Ferriol-Galmes M ; Laguna JC ; Gorría T ; Caravaca G ; Sart J ; Albarrán-Artahona V ; López-Castro R ; Teixidó C ; Castellano G ; Martínez Bedmar A ; Arcocha A ; Alcolea L ; Jiménez M ; Bernabeu M ; Delgado-Cano D ; Navarro A ; Prat A ; Reguart N ; Elio J ; Garrido P ; Leighl NB ; Besse B ; Mezquita L Ther Adv Med Oncol 2025[]; 17 (ä): 17588359251351449 PMID40585875 show ga BACKGROUND: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile. OBJECTIVES: This study aims to explore the potential correlation between estimated indoor radon concentrations and the frequency of driver alterations in NSCLC across Europe. DESIGN: Ecological study of European countries with available data on indoor radon exposure (estimated mean levels and the proportion (%) of dwellings with concentrations >200 and >400?Bq/m(3)), and frequency of NSCLC actionable genomic alterations (EGFR, ALK) from PubMed articles and meeting abstracts with sample size >100 patients. METHODS: We retrospectively analyzed NSCLC molecular data and radon exposure levels from European countries. Radon data, including the mean and proportion (%) of dwellings with concentrations >200 and >400?Bq/m(3), were sourced from the European Commission Report 2005. NSCLC molecular alteration frequency (EGFR, ALK) was extracted from PubMed articles with sample sizes >100 patients. The correlation between molecular alteration frequencies and country-specific radon data were assessed. RESULTS: Data on radon exposure and EGFR/ALK frequency were available for 21 European countries. Five countries had mean radon levels >100?Bq/m(3), and eight countries had ?3% of dwellings with concentrations >400?Bq/m(3). The median frequency of EGFR mutations and ALK fusions was 11.3% (range 7%-18.1%) and 4.1% (range 3.4%-12%), respectively. A positive correlation was found between estimated ALK-fusion frequency and the percentage of dwellings with >400?Bq/m(3) (r?=?0.72, p?=?0.001). No correlation was found between EGFR mutation frequency and radon exposure. CONCLUSION: We found a positive correlation between estimated ALK fusion frequency in NSCLC and the proportion of dwellings exceeding 400?Bq/m(3) radon exposure in 21 European countries. Further research is needed to explore the potential influence of radon and other environmental factors on NSCLC with driver alterations. äFrequency of driver oncogenic alterations in NSCLC and estimated indoo(epmc).pdf DeepDyve Pubget Overpricing