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10.1093/emboj/16.17.5376 http://scihub22266oqcxt.onion/10.1093/emboj/16.17.5376 C1170169!1170169!9311997     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 1997 ; 16 (17): 5376-85 Nephropedia Template TP {{tp|p=9311997|t=1997. The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival |pdf=|usr=}}{{9311997}} gab.com Text The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=9311997 #FOAvip Pathogenicity islands are chromosomal clusters of horizontally acquired virulence genes that are often found at tRNA loci. The selC tRNA locus of Escherichia coli has served as the site of integration of two distinct pathogenicity islands which are responsible for converting benign strains into uro- and enteropathogens. Because virulence genes are targeted to the selC locus of E.coli, we investigated the homologous region of the Salmonella typhimurium chromosome for the presence of horizontally acquired sequences. At this site, we identified a 17 kb DNA segment that is both unique to Salmonella and necessary for virulence. This segment harbors a gene, mgtC, that is required for intramacrophage survival and growth in low Mg2+ media. The mgtC locus is regulated by the PhoP/PhoQ two-component system, a major regulator of virulence functions present in both pathogenic and non-pathogenic bacterial species. Cumulatively, our experiments indicate that the ability to replicate in low Mg2+ environments is necessary for Salmonella virulence, and suggest that a similar mechanism is responsible for the dissemination and acquisition of pathogenicity islands in enteric bacteria. Twit Text FOAVip The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=9311997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9311997 #FOAvip English Wikipedia <ref>{{Cite pmid|9311997}}</ref> The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival #MMPMID9311997 Blanc-Potard AB; Groisman EA EMBO J 1997[Sep]; 16 (17): 5376-85 PMID9311997show ga Pathogenicity islands are chromosomal clusters of horizontally acquired virulence genes that are often found at tRNA loci. The selC tRNA locus of Escherichia coli has served as the site of integration of two distinct pathogenicity islands which are responsible for converting benign strains into uro- and enteropathogens. Because virulence genes are targeted to the selC locus of E.coli, we investigated the homologous region of the Salmonella typhimurium chromosome for the presence of horizontally acquired sequences. At this site, we identified a 17 kb DNA segment that is both unique to Salmonella and necessary for virulence. This segment harbors a gene, mgtC, that is required for intramacrophage survival and growth in low Mg2+ media. The mgtC locus is regulated by the PhoP/PhoQ two-component system, a major regulator of virulence functions present in both pathogenic and non-pathogenic bacterial species. Cumulatively, our experiments indicate that the ability to replicate in low Mg2+ environments is necessary for Salmonella virulence, and suggest that a similar mechanism is responsible for the dissemination and acquisition of pathogenicity islands in enteric bacteria. äThe Salmonella selC locus contains a pathogenicity island mediating in(epmc).pdf DeepDyve Pubget Overpricing