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2024 ; 25
(1
): 250
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Association between lipoprotein (a) and risk of atherosclerotic cardiovascular
disease events among maintenance hemodialysis patients in Beijing, China: a
single-center, retrospective study
#MMPMID39090533
Liang Q
; Zhang G
; Jiang L
BMC Nephrol
2024[Aug]; 25
(1
): 250
PMID39090533
show ga
BACKGROUND: Serum lipoprotein(a) [Lp(a)] is an independent risk factor for
atherosclerotic cardiovascular disease (ASCVD) in the general population, its
association with ASCVD incidence in Chinese maintenance hemodialysis (MHD)
patients remains unclear. We aimed to evaluate the relationship between Lp(a)
levels and ASCVD incidence among MHD patients in Beijing, China. METHODS: This
retrospective, observational cohort study included MHD patients at Beijing
Tongren Hospital from January 1, 2013 to December 1, 2020, and followed until
December 1,2023. The primary outcome was ASCVD occurrence. Kaplan-Meier survival
analysis was used to evaluate ASCVD-free survival in MHD patients, with
stratification based on Lp(a) levels. Cox regression analyses were conducted to
assess the association between Lp(a) levels and the occurrence of ASCVD. RESULTS:
A total of 265 patients were enrolled in the study. The median follow-up period
were 71 months.78 (29.4%) participants experienced ASCVD events, and 118 (47%)
patients died, with 58 (49.1%) deaths attributed to ASCVD. Spearman rank
correlation analyses revealed positive correlations between serum Lp(a) levels
and LDL-c levels, and negative correlations with hemoglobin, triglyceride, serum
iron, serum creatinine, and albumin levels. Multivariate Cox regression analysis
showed that Lp(a) levels???30 mg/L, increased age, decreased serum albumin
levels, and a history of diabetes mellitus were significantly associated with
ASCVD incidence. CONCLUSIONS: This study demonstrated an independent and positive
association between serum Lp(a) levels and the risk of ASCVD in MHD patients,
suggesting that serum Lp(a) could potentially serve as a clinical biomarker for
estimating ASCVD risk in this population.