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2024 ; 16
(7
): 2054-2064
Nephropedia Template TP
gab.com Text
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English Wikipedia
Spleen volume is associated with overt hepatic encephalopathy after transjugular
intrahepatic portosystemic shunt in patients with portal hypertension
#MMPMID39087107
Zhao CJ
; Ren C
; Yuan Z
; Bai GH
; Li JY
; Gao L
; Li JH
; Duan ZQ
; Feng DP
; Zhang H
World J Gastrointest Surg
2024[Jul]; 16
(7
): 2054-2064
PMID39087107
show ga
BACKGROUND: Portal shunt and immune status related to the spleen are related to
the occurrence of hepatic encephalopathy (HE). It is unknown whether spleen
volume before transjugular intrahepatic portosystemic shunt (TIPS) is related to
postoperative HE. AIM: To investigate the relationship between spleen volume and
the occurrence of HE. METHODS: This study included 135 patients with liver
cirrhosis who underwent TIPS, and liver and spleen volumes were elevated upon
computed tomography imaging. The Kaplan-Meier curve was used to compare the
difference in the incidence rate of HE among patients with different spleen
volumes. Univariate and multivariate Cox regression analyses were performed to
identify the factors affecting overt HE (OHE). Restricted cubic spline was used
to examine the shapes of the dose-response association between spleen volumes and
OHE risk. RESULTS: The results showed that 37 (27.2%) of 135 patients experienced
OHE during a 1-year follow-up period. Compared with preoperative spleen volume
(901.30 ± 471.90 cm(3)), there was a significant decrease in spleen volume after
TIPS (697.60 ± 281.0 cm(3)) in OHE patients. As the severity of OHE increased,
the spleen volume significantly decreased (P < 0.05). Compared with patients with
a spleen volume ? 782.4 cm(3), those with a spleen volume < 782.4 cm(3) had a
higher incidence of HE (P < 0.05). Cox regression analysis showed that spleen
volume was an independent risk factor for post-TIPS OHE (hazard ratio = 0.494, P
< 0.05). Restricted cubic spline model showed that with an increasing spleen
volume, OHE risk showed an initial increase and then decrease (P < 0.05).
CONCLUSION: Spleen volume is related to the occurrence of OHE after TIPS.
Preoperative spleen volume is an independent risk factor for post-TIPS OHE.