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2024 ; 16
(7
): 2281-2295
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Construction of prognostic markers for gastric cancer and comprehensive analysis
of pyroptosis-related long non-coding RNAs
#MMPMID39087128
Wang Y
; Li D
; Xun J
; Wu Y
; Wang HL
World J Gastrointest Surg
2024[Jul]; 16
(7
): 2281-2295
PMID39087128
show ga
BACKGROUND: China's most frequent malignancy is gastric cancer (GC), which has a
very poor survival rate, and the survival rate for patients with advanced GC is
dismal. Pyroptosis has been connected to the genesis and development of cancer.
The function of pyroptosis-related long non-coding RNAs (PRLs) in GC, on the
other hand, remains uncertain. AIM: To explore the construction and comprehensive
analysis of the prognostic characteristics of long non-coding RNA (lncRNA)
related to pyroptosis in GC patients. METHODS: The TCGA database provided us with
352 stomach adenocarcinoma samples, and we obtained 28 pyroptotic genes from the
Reactome database. We examined the correlation between lncRNAs and pyroptosis
using the Pearson correlation coefficient. Prognosis-related PRLs were identified
through univariate Cox analysis. A predictive signature was constructed using
stepwise Cox regression analysis, and its reliability and independence were
assessed. To facilitate clinical application, a nomogram was created based on
this signature. we analyzed differences in immune cell infiltration, immune
function, and checkpoints between the high-risk group (HRG) and low-risk group
(LRG). RESULTS: Five hundred and twenty-three PRLs were screened from all lncRNAs
(absolute correlation coefficient > 0.4, P < 0.05). Nine PRLs were included in
the risk prediction signature that was created through stepwise Cox regression
analysis. We determined the risk score for GC patients and employed the median
value as the dividing line between HRG and LRG. The ability of the risk signature
to predict the overall survival (OS) of GC is demonstrated by the Kaplan-Meier
analysis, risk curve, receiver operating characteristic curve, and decision curve
analysis curve. The risk signature was shown to be an independent prognostic
factor for OS in both univariate and multivariate Cox regression analyses. HRG
showed a more efficient local immune response or modulation compared to LRG, as
indicated by the predicted signal pathway analysis and examination of immune cell
infiltration, function, and checkpoints (P < 0.05). CONCLUSION: In general, we
have created a brand-new prognostic signature using PRLs, which may provide ideas
for immunotherapy in patients with GC.