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2024 ; 16
(7
): 2073-2079
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The combined detection of carcinoembryonic antigen, carcinogenic antigen 125, and
carcinogenic antigen 19-9 in colorectal cancer patients
#MMPMID39087124
Gong LZ
; Wang QW
; Zhu JW
World J Gastrointest Surg
2024[Jul]; 16
(7
): 2073-2079
PMID39087124
show ga
BACKGROUND: Hepatic metastases are common and difficult to treat after colorectal
cancer (CRC) surgery. The predictive value of carcinoembryonic antigen (CEA),
cancer antigen (CA) 125 and CA19-9 combined tests for liver metastasis is
unclear. AIM: To evaluate predictive value of combined tests for CEA, CA125, and
CA19-9 levels in patients with liver metastases of CRC. METHODS: The
retrospective study included patients with CRC alone (50 cases) and patients with
CRC combined with liver metastases (50 cases) who were hospitalized between
January 2021 and January 2023. Serum CEA, CA125 and CA19-9 levels were compared
between the two groups, and binary logistic regression was used to analyze the
predictive value of the combination of these tumor markers in liver metastasis.
In addition, we performed receiver operating characteristic (ROC) curve analysis
to assess its diagnostic accuracy. RESULTS: The results showed that the serum
CEA, CA125 and CA19-9 levels in the CRC with liver metastasis group were
significantly higher than those in the CRC alone group. Specifically, the average
serum CEA level in the CRC with liver metastasis group was 162.03 ± 810.01 ng/mL,
while that in the CRC alone group was 5.71 ± 9.76 ng/mL; the average serum CA125
levels were 43.47 ± 83.52 U/mL respectively. and 13.5 ± 19.68 U/mL; the average
serum CA19-9 levels were 184.46 ± 473.13 U/mL and 26.55 ± 43.96 U/mL
respectively. In addition, binary logistic regression analysis showed that CA125
was significant in predicting CRC liver metastasis (P < 0.05). ROC curve analysis
results showed that the areas under the ROC curves of CEA, CA125 and CA19-9 were
0.607, 0.692 and 0.586. CONCLUSION: These results suggest that combined detection
of these tumor markers may help early detection and intervention of CRC liver
metastasis, thereby improving patient prognosis.