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2024 ; 16
(7
): 2127-2134
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Interaction between the albumin-bilirubin score and nutritional risk index in the
prediction of post-hepatectomy liver failure
#MMPMID39087104
Qin FF
; Deng FL
; Huang CT
; Lin SL
; Huang H
; Nong JJ
; Wei MJ
World J Gastrointest Surg
2024[Jul]; 16
(7
): 2127-2134
PMID39087104
show ga
BACKGROUND: Post-hepatectomy liver failure (PHLF) is the most common
postoperative complication and the leading cause of death after hepatectomy. The
albumin-bilirubin (ALBI) score and nutritional risk index (NRI) have been shown
to assess end-stage liver disease and predict PHLF and patient survival. We
hypothesized that the ALBI score and NRI interact in the prediction of PHLF. AIM:
To analyze the interaction between the ALBI score and NRI in PHLF in patients
with hepatocellular carcinoma. METHODS: This retrospective study included 186
patients who underwent hepatectomy for hepatocellular carcinoma at the Affiliated
Hospital of Youjiang Medical University for Nationalities between January 2020
and July 2023. Data on patient characteristics and laboratory indices were
collected from their medical records. Univariate and multivariate logistic
regression were performed to determine the interaction effect between the ALBI
score and NRI in PHLF. RESULTS: Of the 186 patients included in the study, PHLF
occurred in 44 (23.66%). After adjusting for confounders, multivariate logistic
regression identified ALBI grade 2/3 [odds ratio (OR) = 73.713, 95% confidence
interval (CI): 9.175-592.199] and NRI > 97.5 (OR = 58.990, 95%CI: 7.337-474.297)
as risk factors for PHLF. No multiplicative interaction was observed between the
ALBI score and NRI (OR = 0.357, 95%CI: 0.022-5.889). However, the risk of PHLF in
patients with ALBI grade 2/3 and NRI < 97.5 was 101 times greater than that in
patients with ALBI grade 1 and NRI ? 97.5 (95%CI: 56.445-523.839), indicating a
significant additive interaction between the ALBI score and NRI in PHLF.
CONCLUSION: Both the ALBI score and NRI were risk factors for PHLF, and there was
an additive interaction between the ALBI score and NRI in PHLF.