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2024 ; 16
(7
): 1969-1972
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Impact of immunotherapy on liver metastasis
#MMPMID39087120
Fu Z
; Wang MW
; Liu YH
; Jiao Y
World J Gastrointest Surg
2024[Jul]; 16
(7
): 1969-1972
PMID39087120
show ga
This editorial discusses the article "Analysis of the impact of immunotherapy
efficacy and safety in patients with gastric cancer and liver metastasis"
published in the latest edition of the World Journal of Gastrointestinal Surgery.
Immunotherapy has achieved outstanding success in tumor treatment. However, the
presence of liver metastasis (LM) restrains the efficacy of immunotherapy in
various tumors, including lung cancer, colorectal cancer, renal cell carcinoma,
melanoma, and gastric cancer. A decrease in CD8+ T cells and nature killer cells,
along with an increase in macrophages and regulatory T cells, was observed in the
microenvironment of LM, leading to immunotherapy resistance. More studies are
necessary to determine the best strategy for enhancing the effectiveness of
immunotherapy in patients with LM.
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