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2024 ; 16
(7
): 422-435
Nephropedia Template TP
gab.com Text
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English Wikipedia
Network pharmacology-based exploration of molecular mechanisms underlying
therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with
spleen Qi deficiency syndrome
#MMPMID39086892
Li SQ
; Min DY
; Jiang JW
; Li XY
; Yang XN
; Gu WB
; Jiang JH
; Chen LH
; Nan H
; Chen ZY
World J Cardiol
2024[Jul]; 16
(7
): 422-435
PMID39086892
show ga
BACKGROUND: Chronic heart failure is a complex clinical syndrome. The Chinese
herbal compound preparation Jianpi Huatan Quyu recipe has been used to treat
chronic heart failure; however, the underlying molecular mechanism is still not
clear. AIM: To identify the effective active ingredients of Jianpi Huatan Quyu
recipe and explore its molecular mechanism in the treatment of chronic heart
failure. METHODS: The effective active ingredients of eight herbs composing
Jianpi Huatan Quyu recipe were identified using the Traditional Chinese Medicine
Systems Pharmacology Database and Analysis Platform. The target genes of chronic
heart failure were searched in the Genecards database. The target proteins of
active ingredients were mapped to chronic heart failure target genes to obtain
the common drug-disease targets, which were then used to construct a key chemical
component-target network using Cytoscape 3.7.2 software. The protein-protein
interaction network was constructed using the String database. Gene Ontology and
Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed
through the Metascape database. Finally, our previously published relevant
articles were searched to verify the results obtained via network pharmacology.
RESULTS: A total of 227 effective active ingredients for Jianpi Huatan Quyu
recipe were identified, of which quercetin, kaempferol, 7-methoxy-2-methyl
isoflavone, formononetin, and isorhamnetin may be key active ingredients and
involved in the therapeutic effects of TCM by acting on STAT3, MAPK3, AKT1, JUN,
MAPK1, TP53, TNF, HSP90AA1, p65, MAPK8, MAPK14, IL6, EGFR, EDN1, FOS, and other
proteins. The pathways identified by KEGG enrichment analysis include pathways in
cancer, IL-17 signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling
pathway, calcium signaling pathway, cAMP signaling pathway, NF-kappaB signaling
pathway, AMPK signaling pathway, etc. Previous studies on Jianpi Huatan Quyu
recipe suggested that this Chinese compound preparation can regulate the TNF-?,
IL-6, MAPK, cAMP, and AMPK pathways to affect the mitochondrial structure of
myocardial cells, oxidative stress, and energy metabolism, thus achieving the
therapeutic effects on chronic heart failure. CONCLUSION: The Chinese medicine
compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on
chronic heart failure possibly by influencing the mitochondrial structure of
cardiomyocytes, oxidative stress, energy metabolism, and other processes. Future
studies are warranted to investigate the role of the IL-17 signaling pathway,
PI3K-Akt signaling pathway, HIF-1 signaling pathway, and other pathways in
mediating the therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart
failure.