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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Diagn+Lab+Immunol 2005 ; 12 (5): 671-6 Nephropedia Template TP
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Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders #MMPMID15879032
Matsunaga H; Tanaka S; Sasao F; Nishino Y; Takeda M; Tomonaga K; Ikuta K; Amino N
Clin Diagn Lab Immunol 2005[May]; 12 (5): 671-6 PMID15879032show ga
Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively. Compared with results by Western blotting, three and nine sera were concordantly positive, respectively. The four sera showing the highest levels of antibodies by radioligand assay were all negative by Western blotting; however, dilution and inhibition tests supported the positive results. Our results suggest the importance of conformational structure to detect human anti-Borna disease virus antibodies.