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10.1128/JVI.79.7.4514-4518.2005 http://scihub22266oqcxt.onion/10.1128/JVI.79.7.4514-4518.2005 C1061581!1061581!15767452     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2005 ; 79 (7): 4514-8 Nephropedia Template TP {{tp|p=15767452|t=2005. Mechanism of the Antiviral Action of 1-?-d-Arabinofuranosylcytosine on Borna Disease Virus |pdf=|usr=}}{{15767452}} gab.com Text Mechanism of the Antiviral Action of 1- -d-Arabinofuranosylcytosine on Borna Disease Virus JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=15767452 #FOAvip Borna disease virus (BDV) is a nonsegmented, negative-stranded RNA virus that causes neurological diseases in a variety of warm-blooded animal species. Recently, we showed that the nucleoside analog 1-?-d-arabinofuranosylcytosine (Ara-C) was a potent inhibitor of BDV. This finding was surprising for an RNA virus, since Ara-C is a DNA polymerase inhibitor. Thus, we sought to better define the mechanism of action of Ara-C on BDV. Here, we show that (i) this effect is specific for an arabinoside ring carrying a cytosine base, (ii) it requires phosphorylation of the nucleotide, and (iii) it can be reversed by an excess of cytidine. Using the recently described minigenome assay for BDV, we provide evidence suggesting that Ara-C may act as a competitive inhibitor of the BDV replication complex. Twit Text FOAVip Mechanism of the Antiviral Action of 1- -d-Arabinofuranosylcytosine on Borna Disease Virus ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=15767452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15767452 #FOAvip English Wikipedia <ref>{{Cite pmid|15767452}}</ref> Mechanism of the Antiviral Action of 1-?-d-Arabinofuranosylcytosine on Borna Disease Virus #MMPMID15767452 Volmer R; Bajramovic JJ; Schneider U; Ufano S; Pochet S; Gonzalez-Dunia D J Virol 2005[Apr]; 79 (7): 4514-8 PMID15767452show ga Borna disease virus (BDV) is a nonsegmented, negative-stranded RNA virus that causes neurological diseases in a variety of warm-blooded animal species. Recently, we showed that the nucleoside analog 1-?-d-arabinofuranosylcytosine (Ara-C) was a potent inhibitor of BDV. This finding was surprising for an RNA virus, since Ara-C is a DNA polymerase inhibitor. Thus, we sought to better define the mechanism of action of Ara-C on BDV. Here, we show that (i) this effect is specific for an arabinoside ring carrying a cytosine base, (ii) it requires phosphorylation of the nucleotide, and (iii) it can be reversed by an excess of cytidine. Using the recently described minigenome assay for BDV, we provide evidence suggesting that Ara-C may act as a competitive inhibitor of the BDV replication complex. äMechanism of the Antiviral Action of 1-?-d-Arabinofuranosylcytosine on(epmc).pdf DeepDyve Pubget Overpricing