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Borna Disease in a Dog with Lethal Meningoencephalitis #MMPMID9650982
Weissenböck H; Nowotny N; Caplazi P; Kolodziejek J; Ehrensperger F
J Clin Microbiol 1998[Jul]; 36 (7): 2127-30 PMID9650982show ga
A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.