Effect of Immune Priming on Borna Disease #MMPMID9971840
Lewis AJ; Whitton JL; Hatalski CG; Weissenböck H; Lipkin WI
J Virol 1999[Mar]; 73 (3): 2541-6 PMID9971840show ga
Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.