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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Gen+Virol 1998 ; 79 ( Pt 12) (ä): 2957-63 Nephropedia Template TP
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Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein #MMPMID9880009
Berg M; Ehrenborg C; Blomberg J; Pipkorn R; Berg AL
J Gen Virol 1998[Dec]; 79 ( Pt 12) (ä): 2957-63 PMID9880009show ga
Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190. By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein. These proteins are known to form complexes with each other and with the polymerase protein in other viruses. In this paper, it is shown that BDV p40 and p23 can form complexes with each other in infected cells. Furthermore, the amino acids of p40 that are necessary for formation of this complex have been mapped.