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10.1016/S0140-6736(98)06165-0

http://scihub22266oqcxt.onion/10.1016/S0140-6736(98)06165-0
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9848349!ä!9848349

suck abstract from ncbi


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pmid9848349      Lancet 1998 ; 352 (9142): 1739-41
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  • Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children #MMPMID9848349
  • Sokal EM; Melchior M; Cornu C; Vandenbroucke AT; Buts JP; Cohen BJ; Burtonboy G
  • Lancet 1998[Nov]; 352 (9142): 1739-41 PMID9848349show ga
  • BACKGROUND: The cause of fulminant hepatitis (FH) in children is unexplained in up to 50% of cases. We report parvovirus B19 as an agent associated with FH in children and compare clinical characteristics of these patients with those of age-matched patients with FH of other origin. METHODS: 45 patients presented with FH. No cause was apparent in 21 patients. Parvovirus B19 genome was retrospectively sought by PCR in serum collected at admission in 41 patients. FINDINGS: Parvovirus B19 genome was detected in serum from four of 21 patients with unexplained FH (four of 11 younger than 5 years). No B19 DNA was detected in serum from patients with other types of FH or from 82 patients with biliary atresia. Parvovirus B19 IgM was detected in one of the four patients. Patients with parvovirus B19 infection had significantly lower bilirubin concentrations than age-matched patients with FH due to hepatitis A (nine) or other causes (nine) (poisoning with amanita excluded). All patients with parvovirus B19 survived without orthotopic liver transplantation, with restoration of normal liver function within 17 days. INTERPRETATION: In patients younger than 5 years with FH of unexplained origin, evidence of acute parvovirus B19 was associated with a distinct clinical pattern. In particular, low bilirubin concentrations and rapid recovery of liver function without transplantation were distinctive features.
  • |*Parvovirus B19, Human/genetics[MESH]
  • |Child, Preschool[MESH]
  • |Genome, Viral[MESH]
  • |Hepatic Encephalopathy/diagnosis/mortality/*virology[MESH]
  • |Hepatitis, Viral, Human/diagnosis/mortality/*virology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Liver Function Tests[MESH]
  • |Parvoviridae Infections/diagnosis/*virology[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]


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