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10.1006/exmp.1998.2232 http://scihub22266oqcxt.onion/10.1006/exmp.1998.2232 9828151!ä!9828151 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Pathol 1998 ; 65 (2): 104-9 Nephropedia Template TP {{tp|p=9828151|t=1998. Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets |pdf=|usr=}}{{9828151}} gab.com Text Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets JO: Exp Mol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=9828151 #FOAvip Magnesium (Mg2+), the second most abundant intracellular cation, is a critical cofactor in numerous enzymatic reactions. After stimulation of platelets with insulin and insulin-like growth factor-1 (IGF-1), we examined changes in cytosolic free Mg2+ ([Mg2+]i) by using fluorescent probe magfura-2. Basal [Mg2+]i in platelets was 614 +/- 1 microM (mean +/- SEM, n = 60). Insulin and IGF-1 induced an immediate rise of [Mg2+]i in a dose-dependent manner. After stimulation of platelets with 100 microU/mL of insulin for 60 s, [Mg2+]i was significantly elevated to 1270 +/- 53 microM (n = 30, P < 0.05), i.e., 82 +/- 5% over resting [Mg2+]i. IGF-1 (5 micrograms/mL) also increased [Mg2+]i (1020 +/- 53 microM, 69 +/- 10% over resting [Mg2+]i, n = 30). In the medium containing choline instead of sodium or the medium without potassium, an elevation of [Mg2+]i with addition of insulin/IGF-1 was moderately suppressed. Amiloride, a Na+-H+ antiport inhibitor, did not block the insulin/IGF-1 effect. Insulin/ IGF-1 translocates Mg2+ from the extracellular space to intracellular space and these effects are affected by external sodium and potassium. Twit Text FOAVip Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets ????Exp Mol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=9828151 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9828151 #FOAvip English Wikipedia <ref>{{Cite pmid|9828151}}</ref> Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets #MMPMID9828151 Takaya J; Higashino H; Miyazaki R; Kobayashi Y Exp Mol Pathol 1998[Oct]; 65 (2): 104-9 PMID9828151show ga Magnesium (Mg2+), the second most abundant intracellular cation, is a critical cofactor in numerous enzymatic reactions. After stimulation of platelets with insulin and insulin-like growth factor-1 (IGF-1), we examined changes in cytosolic free Mg2+ ([Mg2+]i) by using fluorescent probe magfura-2. Basal [Mg2+]i in platelets was 614 +/- 1 microM (mean +/- SEM, n = 60). Insulin and IGF-1 induced an immediate rise of [Mg2+]i in a dose-dependent manner. After stimulation of platelets with 100 microU/mL of insulin for 60 s, [Mg2+]i was significantly elevated to 1270 +/- 53 microM (n = 30, P < 0.05), i.e., 82 +/- 5% over resting [Mg2+]i. IGF-1 (5 micrograms/mL) also increased [Mg2+]i (1020 +/- 53 microM, 69 +/- 10% over resting [Mg2+]i, n = 30). In the medium containing choline instead of sodium or the medium without potassium, an elevation of [Mg2+]i with addition of insulin/IGF-1 was moderately suppressed. Amiloride, a Na+-H+ antiport inhibitor, did not block the insulin/IGF-1 effect. Insulin/ IGF-1 translocates Mg2+ from the extracellular space to intracellular space and these effects are affected by external sodium and potassium. |Amiloride/pharmacology[MESH] |Blood Platelets/*drug effects/metabolism[MESH] |Choline/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Insulin-Like Growth Factor I/*pharmacology[MESH] |Insulin/*pharmacology[MESH] |Intracellular Fluid/metabolism[MESH]Effects of insulin and insulin-like growth factor-1 on intracellular m(epmc).pdf DeepDyve Pubget Overpricing