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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Life+Sci 1998 ; 63 (20): 1815-22 Nephropedia Template TP
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Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis #MMPMID9820125
Malpuech-Brugere C; Rock E; Astier C; Nowacki W; Mazur A; Rayssiguier Y
Life Sci 1998[]; 63 (20): 1815-22 PMID9820125show ga
The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.