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10.1016/s0165-5728(98)00066-6

http://scihub22266oqcxt.onion/10.1016/s0165-5728(98)00066-6
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9817440!ä!9817440

suck abstract from ncbi


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pmid9817440      J+Neuroimmunol 1998 ; 90 (2): 128-36
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  • Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus #MMPMID9817440
  • Hatalski CG; Hickey WF; Lipkin WI
  • J Neuroimmunol 1998[Oct]; 90 (2): 128-36 PMID9817440show ga
  • The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa light chain mRNA-containing cells in brain and accumulation of virus-specific antibodies in cerebrospinal fluid. Treatment with BD-rat serum altered viral gene expression in persistently infected cultured rat glioblastoma cells. These data suggest that antibodies, produced in the brain, may influence viral gene expression.
  • |Animals[MESH]
  • |Antibodies, Viral/*biosynthesis/physiology[MESH]
  • |Blood-Brain Barrier[MESH]
  • |Borna Disease/*immunology[MESH]
  • |Borna disease virus/genetics/immunology[MESH]
  • |Brain/*immunology[MESH]
  • |Gene Expression Regulation, Viral[MESH]
  • |Immunoglobulin G/biosynthesis[MESH]
  • |Immunoglobulin Isotypes/biosynthesis[MESH]
  • |Immunoglobulin kappa-Chains/genetics[MESH]
  • |RNA, Messenger/analysis[MESH]
  • |Rats[MESH]


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