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10.1016/S0002-9440(10)65656-8 http://scihub22266oqcxt.onion/10.1016/S0002-9440(10)65656-8 9777943/?report=reader!1853060!9777943     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9777943&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 1998 ; 153 (4): 1123-30 Nephropedia Template TP {{tp|p=9777943|t=1998. Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus |pdf=|usr=}}{{9777943}} gab.com Text Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=9777943 #FOAvip Although many human immunodeficiency virus-infected individuals develop lymphocytic interstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not well defined. Human immunodeficiency virus-infected children with lymphocytic interstitial pneumonia have human immunodeficiency virus-specific cytotoxic T cells in pulmonary infiltrates, increased survival time, and a reduced incidence of opportunistic infections, suggesting that lymphocytic interstitial pneumonia may reflect an effective antiviral immune response. In this study, 20 macaques were inoculated with related macrophage-tropic simian immunodeficiency viruses and examined for pulmonary lesions and virus gene expression. Ten macaques developed moderate to severe pneumonia characterized by perivascular, peribronchial, and interstitial infiltrates of lymphocytes and macrophages. Large numbers of pulmonary cytotoxic lymphocytes were demonstrated in macaques with moderate to severe pneumonia (P < 0.05) by immunostaining for TIA-1. There was no difference in viral load between macaques with moderate to severe pneumonia and those with mild to no pulmonary lesions. In five macaques inoculated with the same virus swarm, there was a significant (P < 0.05) inverse correlation between the percentage decline in CD4+ T-cell counts and the severity of pulmonary lesions. Pulmonary infiltrates of cytotoxic lymphocytes, the lack of correlation between severity of pulmonary lesions and virus gene expression, and the inverse relationship between pneumonia and inmune status suggest that simian immunodeficiency virus pneumonia may represent an immunopathological response to macrophage-tropic virus. Twit Text FOAVip Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=9777943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9777943 #FOAvip English Wikipedia <ref>{{Cite pmid|9777943}}</ref> Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus #MMPMID9777943 Mankowski JL; Carter DL; Spelman JP; Nealen ML; Maughan KR; Kirstein LM; Didier PJ; Adams RJ; Murphey-Corb M; Zink MC Am J Pathol 1998[Oct]; 153 (4): 1123-30 PMID9777943show ga Although many human immunodeficiency virus-infected individuals develop lymphocytic interstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not well defined. Human immunodeficiency virus-infected children with lymphocytic interstitial pneumonia have human immunodeficiency virus-specific cytotoxic T cells in pulmonary infiltrates, increased survival time, and a reduced incidence of opportunistic infections, suggesting that lymphocytic interstitial pneumonia may reflect an effective antiviral immune response. In this study, 20 macaques were inoculated with related macrophage-tropic simian immunodeficiency viruses and examined for pulmonary lesions and virus gene expression. Ten macaques developed moderate to severe pneumonia characterized by perivascular, peribronchial, and interstitial infiltrates of lymphocytes and macrophages. Large numbers of pulmonary cytotoxic lymphocytes were demonstrated in macaques with moderate to severe pneumonia (P < 0.05) by immunostaining for TIA-1. There was no difference in viral load between macaques with moderate to severe pneumonia and those with mild to no pulmonary lesions. In five macaques inoculated with the same virus swarm, there was a significant (P < 0.05) inverse correlation between the percentage decline in CD4+ T-cell counts and the severity of pulmonary lesions. Pulmonary infiltrates of cytotoxic lymphocytes, the lack of correlation between severity of pulmonary lesions and virus gene expression, and the inverse relationship between pneumonia and inmune status suggest that simian immunodeficiency virus pneumonia may represent an immunopathological response to macrophage-tropic virus. |*Proteins[MESH] |Animals[MESH] |Antigens, Viral/analysis[MESH] |CD4 Lymphocyte Count[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |Cytotoxicity, Immunologic[MESH] |DNA Primers/chemistry[MESH] |Genes, Viral/genetics[MESH] |In Situ Hybridization[MESH] |Lung/pathology/virology[MESH] |Macaca fascicularis[MESH] |Macaca mulatta[MESH] |Macaca nemestrina[MESH] |Macrophages/virology[MESH] |Membrane Proteins/metabolism[MESH] |Pneumonia, Viral/etiology/*immunology/*pathology[MESH] |RNA, Viral/analysis[MESH] |RNA-Binding Proteins/metabolism[MESH] |Simian Acquired Immunodeficiency Syndrome/*etiology/immunology/pathology[MESH] |Simian Immunodeficiency Virus/genetics/immunology/*physiology[MESH] |T-Lymphocytes, Cytotoxic/immunology/pathology[MESH] |Viral Load[MESH]Pathogenesis of simian immunodeficiency virus pneumonia: an immunopath(epmc).pdf DeepDyve Pubget Overpricing