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10.1002/(sici)1097-4644(19980901)70:3<313::aid-jcb4>3.0.co;2-q 3.0.co;2-q target="_blank">http://scihub22266oqcxt.onion/10.1002/(sici)1097-4644(19980901)70:3<313::aid-jcb4>3.0.co;2-q 9706868!ä!9706868 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9706868&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biochem 1998 ; 70 (3): 313-22 Nephropedia Template TP {{tp|p=9706868|t=1998. Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells |pdf=|usr=}}{{9706868}} gab.com Text Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=9706868 #FOAvip When cultured in Mg restricted medium, human leukemic HL-60 cells develop morphological and functional granulocytic differentiation. In 0.03 mM Mg, cells display the distinctive features of differentiation, without appreciable inhibition of proliferation. In 0.01 mM Mg, cells show terminal differentiation, accompanied by clear inhibition of proliferation. Such cells accumulate in the G0/G1 phase and subsequently die via apoptosis, similar to HL-60 cells that have been induced to differentiate by DMSO. These phenotypic changes are associated with a marked increase in the expression level of the cyclin dependent kinase inhibitor p27Kip1. Cyclin E expression is also slightly increased in Mg restricted cells, whereas no changes are observed in the expression level of cyclin D1. We also show that during differentiation cell total Mg decreases, whereas [Mg2+]i increases in both Mg-depleted and DMSO-treated cells. These data suggest that the maturation process is paralleled by a redistribution of intracellular Mg, leading to a shift from the bound to the free form. These changes could modulate the kinetics of Mg-dependent enzyme(s) that are involved in the control of the differentiation pathway. We propose that this model may represent an useful tool for the study of the mechanisms of cell differentiation and related events, such as aging and death. Twit Text FOAVip Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=9706868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9706868 #FOAvip English Wikipedia <ref>{{Cite pmid|9706868}}</ref> Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells #MMPMID9706868 Covacci V; Bruzzese N; Sgambato A; Di Francesco A; Russo MA; Wolf FI; Cittadini A J Cell Biochem 1998[Sep]; 70 (3): 313-22 PMID9706868show ga When cultured in Mg restricted medium, human leukemic HL-60 cells develop morphological and functional granulocytic differentiation. In 0.03 mM Mg, cells display the distinctive features of differentiation, without appreciable inhibition of proliferation. In 0.01 mM Mg, cells show terminal differentiation, accompanied by clear inhibition of proliferation. Such cells accumulate in the G0/G1 phase and subsequently die via apoptosis, similar to HL-60 cells that have been induced to differentiate by DMSO. These phenotypic changes are associated with a marked increase in the expression level of the cyclin dependent kinase inhibitor p27Kip1. Cyclin E expression is also slightly increased in Mg restricted cells, whereas no changes are observed in the expression level of cyclin D1. We also show that during differentiation cell total Mg decreases, whereas [Mg2+]i increases in both Mg-depleted and DMSO-treated cells. These data suggest that the maturation process is paralleled by a redistribution of intracellular Mg, leading to a shift from the bound to the free form. These changes could modulate the kinetics of Mg-dependent enzyme(s) that are involved in the control of the differentiation pathway. We propose that this model may represent an useful tool for the study of the mechanisms of cell differentiation and related events, such as aging and death. |*Cell Cycle Proteins[MESH] |*Cell Differentiation[MESH] |*Tumor Suppressor Proteins[MESH] |Adenine Nucleotides/metabolism[MESH] |Apoptosis[MESH] |Cell Count[MESH] |Cell Cycle[MESH] |Cyclin D1/metabolism[MESH] |Cyclin E/metabolism[MESH] |Cyclin-Dependent Kinase Inhibitor p27[MESH] |Dimethyl Sulfoxide/pharmacology[MESH] |Granulocytes/*cytology[MESH] |HL-60 Cells[MESH] |Humans[MESH] |Macrophage-1 Antigen/biosynthesis[MESH] |Magnesium/*metabolism[MESH] |Microscopy, Electron[MESH] |Microtubule-Associated Proteins/*biosynthesis[MESH] |Reactive Oxygen Species/metabolism[MESH] |Tetradecanoylphorbol Acetate/pharmacology[MESH]Magnesium restriction induces granulocytic differentiation and express(epmc).pdf DeepDyve Pubget Overpricing