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10.1016/s0165-5728(97)00249-x http://scihub22266oqcxt.onion/10.1016/s0165-5728(97)00249-x 9628458!ä!9628458 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroimmunol 1998 ; 84 (2): 158-63 Nephropedia Template TP {{tp|p=9628458|t=1998. In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection |pdf=|usr=}}{{9628458}} gab.com Text In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection JO: J Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=9628458 #FOAvip Borna disease virus (BDV) infection of the rat brain induces a severe T-lymphocyte mediated inflammatory response that parallels the course of clinical Borna disease. In other models of CNS inflammation, the recruitment of T-lymphocytes from the circulation to sites of inflammation is believed to be directed, in part, by the cellular adhesion molecules alpha4 beta1 integrin (expressed on T-lymphocytes) and its ligand VCAM-1 (expressed on blood brain barrier endothelium). Since BDV-specific T-lymphocytes are known to express the alpha4 beta1 integrin, we examined the effect of in vivo treatment with an anti-alpha4 integrin monoclonal antibody (GG5/3) on the development of BDV-specific encephalitis and Borna disease. Here, we report that the inhibition of alpha4 integrin provided significant clinical benefit in slowing the progression of Borna disease. Antibody treatment greatly reduced the immune cell infiltrates in the CNS of BDV-infected animals, but we found that this inhibition of the immune response did not result in enhanced viral levels. Twit Text FOAVip In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection ????J Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=9628458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9628458 #FOAvip English Wikipedia <ref>{{Cite pmid|9628458}}</ref> In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection #MMPMID9628458 Rubin SA; Yednock TA; Carbone KM J Neuroimmunol 1998[Apr]; 84 (2): 158-63 PMID9628458show ga Borna disease virus (BDV) infection of the rat brain induces a severe T-lymphocyte mediated inflammatory response that parallels the course of clinical Borna disease. In other models of CNS inflammation, the recruitment of T-lymphocytes from the circulation to sites of inflammation is believed to be directed, in part, by the cellular adhesion molecules alpha4 beta1 integrin (expressed on T-lymphocytes) and its ligand VCAM-1 (expressed on blood brain barrier endothelium). Since BDV-specific T-lymphocytes are known to express the alpha4 beta1 integrin, we examined the effect of in vivo treatment with an anti-alpha4 integrin monoclonal antibody (GG5/3) on the development of BDV-specific encephalitis and Borna disease. Here, we report that the inhibition of alpha4 integrin provided significant clinical benefit in slowing the progression of Borna disease. Antibody treatment greatly reduced the immune cell infiltrates in the CNS of BDV-infected animals, but we found that this inhibition of the immune response did not result in enhanced viral levels. |Animals[MESH] |Antibodies, Monoclonal/*pharmacology[MESH] |Antibodies, Viral/blood[MESH] |Antigens, CD/*immunology[MESH] |Borna Disease/*immunology/prevention & control/therapy[MESH] |Encephalitis, Viral/immunology/therapy[MESH] |Integrin alpha4[MESH] |Male[MESH] |RNA Viruses/*immunology[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH] |Receptors, Lymphocyte Homing/immunology[MESH] |Viral Load[MESH]In vivo treatment with anti-alpha4 integrin suppresses clinical and pa(epmc).pdf DeepDyve Pubget Overpricing