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10.1038/32183 http://scihub22266oqcxt.onion/10.1038/32183 9510252!ä!9510252 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9510252&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 1998 ; 392 (6671): 86-9 Nephropedia Template TP {{tp|p=9510252|t=1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs |pdf=|usr=}}{{9510252}} gab.com Text Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=9510252 #FOAvip CD8+ cytotoxic T lymphocytes (CTLs) mediate resistance to infectious agents and tumours. Classically, CTLs recognize antigens that are localized in the cytoplasm of target cells, processed and presented as peptide complexes with class I molecules of the major histocompatibility complex (MHC). However, there is evidence for an exogenous pathway whereby antigens that are not expected to gain access to the cytoplasm are presented on MHC class I molecules. The most dramatic example is the in vivo phenomenon of cross-priming: antigens from donor cells are acquired by bone-marrow-derived host antigen-presenting cells (APCs) and presented on MHC class I molecules. Two unanswered questions concern the identity of this bone-marrow-derived cell and how such antigens are acquired. Here we show that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs. Our findings suggest a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of CTLs. Twit Text FOAVip Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=9510252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9510252 #FOAvip English Wikipedia <ref>{{Cite pmid|9510252}}</ref> Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs #MMPMID9510252 Albert ML; Sauter B; Bhardwaj N Nature 1998[Mar]; 392 (6671): 86-9 PMID9510252show ga CD8+ cytotoxic T lymphocytes (CTLs) mediate resistance to infectious agents and tumours. Classically, CTLs recognize antigens that are localized in the cytoplasm of target cells, processed and presented as peptide complexes with class I molecules of the major histocompatibility complex (MHC). However, there is evidence for an exogenous pathway whereby antigens that are not expected to gain access to the cytoplasm are presented on MHC class I molecules. The most dramatic example is the in vivo phenomenon of cross-priming: antigens from donor cells are acquired by bone-marrow-derived host antigen-presenting cells (APCs) and presented on MHC class I molecules. Two unanswered questions concern the identity of this bone-marrow-derived cell and how such antigens are acquired. Here we show that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs. Our findings suggest a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of CTLs. |*Antigen Presentation[MESH] |*Apoptosis[MESH] |*Lymphocyte Activation[MESH] |Antigens, Viral/immunology[MESH] |Cell Line[MESH] |Coculture Techniques[MESH] |Dendritic Cells/*immunology[MESH] |HLA-A2 Antigen/immunology[MESH] |Histocompatibility Antigens Class I/*immunology[MESH] |Humans[MESH] |Influenza A virus/immunology[MESH] |Macrophages/immunology[MESH] |Monocytes/immunology[MESH]Dendritic cells acquire antigen from apoptotic cells and induce class (epmc).pdf DeepDyve Pubget Overpricing