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10.1002/(sici)1099-1263(199711/12)17:6<409::aid-jat462>3.0.co;2-b 3.0.co;2-b target="_blank">http://scihub22266oqcxt.onion/10.1002/(sici)1099-1263(199711/12)17:6<409::aid-jat462>3.0.co;2-b 9418950!ä!9418950 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Appl+Toxicol 1997 ; 17 (6): 409-13 Nephropedia Template TP {{tp|p=9418950|t=1997. Influence of atenolol and/or metformin on glutathione and magnesium levels in diabetic rats |pdf=|usr=}}{{9418950}} gab.com Text Influence of atenolol and/or metformin on glutathione and magnesium levels in diabetic rats JO: J Appl Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=9418950 #FOAvip Recently there has been growing interest in studying the differences between different classes of antihypertensive drugs in preventing cardiovascular events in diabetic patients. Hypomagnesemia is common in diabetes mellitus, and correlates to its chronic complications and the associated alteration of the antioxidant enzyme activity. Depletion of reduced glutathione (GSH) in the blood has been demonstrated with myocardial injuries associating hypomagnesemia. A previous study has demonstrated a beneficial effect of metformin hydrochloride (Met), an antihyperglycemic drug, on both magnesium (Mg) and GSH levels in diabetic animals. The purpose of this study was to investigate the effect of oral atenolol, metformin (50 and 60 mg kg[-1] day[-1], respectively) and their combination for 14 days on Mg and GSH levels in blood, liver and heart of diabetic male Wistar rats, as these two parameters have been shown to be altered in diabetics and linked to myocardial ischemic injuries. The results of this investigation showed a state of low levels of Mg and GSH in both blood and liver of the diabetic animals. Treatment with atenolol alone did not change these levels significantly, however administration of metformin or atenolol/metformin increased significantly the GSH levels in both liver and blood, and returned the liver Mg content back to normal values. Twit Text FOAVip Influence of atenolol and/or metformin on glutathione and magnesium levels in diabetic rats ????J Appl Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=9418950 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9418950 #FOAvip English Wikipedia <ref>{{Cite pmid|9418950}}</ref> Influence of atenolol and/or metformin on glutathione and magnesium levels in diabetic rats #MMPMID9418950 Ewis SA; Abdel-Rahman MS J Appl Toxicol 1997[Nov]; 17 (6): 409-13 PMID9418950show ga Recently there has been growing interest in studying the differences between different classes of antihypertensive drugs in preventing cardiovascular events in diabetic patients. Hypomagnesemia is common in diabetes mellitus, and correlates to its chronic complications and the associated alteration of the antioxidant enzyme activity. Depletion of reduced glutathione (GSH) in the blood has been demonstrated with myocardial injuries associating hypomagnesemia. A previous study has demonstrated a beneficial effect of metformin hydrochloride (Met), an antihyperglycemic drug, on both magnesium (Mg) and GSH levels in diabetic animals. The purpose of this study was to investigate the effect of oral atenolol, metformin (50 and 60 mg kg[-1] day[-1], respectively) and their combination for 14 days on Mg and GSH levels in blood, liver and heart of diabetic male Wistar rats, as these two parameters have been shown to be altered in diabetics and linked to myocardial ischemic injuries. The results of this investigation showed a state of low levels of Mg and GSH in both blood and liver of the diabetic animals. Treatment with atenolol alone did not change these levels significantly, however administration of metformin or atenolol/metformin increased significantly the GSH levels in both liver and blood, and returned the liver Mg content back to normal values. |Animals[MESH] |Antihypertensive Agents/*pharmacology[MESH] |Atenolol/*pharmacology[MESH] |Blood Glucose/drug effects[MESH] |Body Weight/drug effects[MESH] |Diabetes Mellitus, Experimental/drug therapy/*metabolism[MESH] |Drug Combinations[MESH] |Glutathione/*metabolism[MESH] |Hypoglycemic Agents/*pharmacology[MESH] |Liver/metabolism[MESH] |Magnesium/*metabolism[MESH] |Male[MESH] |Metformin/*pharmacology[MESH] |Myocardium/metabolism[MESH] |Organ Size/drug effects[MESH] |Rats[MESH]Influence of atenolol and/or metformin on glutathione and magnesium le(epmc).pdf DeepDyve Pubget Overpricing