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10.1007/s007050050220

http://scihub22266oqcxt.onion/10.1007/s007050050220
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9413511!ä!9413511

suck abstract from ncbi


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pmid9413511      Arch+Virol 1997 ; 142 (10): 2035-42
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  • Amantadine does not have antiviral activity against Borna disease virus #MMPMID9413511
  • Cubitt B; de la Torre JC
  • Arch Virol 1997[]; 142 (10): 2035-42 PMID9413511show ga
  • We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.
  • |Amantadine/analogs & derivatives/*pharmacology[MESH]
  • |Animals[MESH]
  • |Antigens, Viral/metabolism[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Borna disease virus/*drug effects/genetics/metabolism[MESH]
  • |Cell Line[MESH]
  • |Dogs[MESH]
  • |RNA, Viral/metabolism[MESH]
  • |Rabbits[MESH]
  • |Rats[MESH]
  • |Tumor Cells, Cultured[MESH]


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