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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Brain+Res 1997 ; 770 (1-2): 307-9 Nephropedia Template TP
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Detection of Borna disease virus genome in normal human brain tissue #MMPMID9372235
Haga S; Yoshimura M; Motoi Y; Arima K; Aizawa T; Ikuta K; Tashiro M; Ikeda K
Brain Res 1997[Oct]; 770 (1-2): 307-9 PMID9372235show ga
Borna disease virus (BDV), a neurotropic virus naturally infecting horses and sheep, has been suggested to be associated with human psychiatric disorders. Thus far no extensive studies have been done, providing the evidence of BDV genome in normal human brain tissue. We therefore examined four brain regions of 30 normal autopsy brains for BDV p24 genome. By highly sensitive nested reverse transcriptase (RT)-mediated PCR analysis, we found positive PCR products in two brains: one in frontal and temporal cortices and hippocampus and another in frontal cortex and olfactory bulb. Our results suggest that BDV can infect human brain tissue latently, without causing an apparent neuropsychiatric disorder.