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10.1038/36285

http://scihub22266oqcxt.onion/10.1038/36285
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9363890!ä!9363890

suck abstract from ncbi


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pmid9363890      Nature 1997 ; 390 (6655): 45-51
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  • Mutation of the mouse klotho gene leads to a syndrome resembling ageing #MMPMID9363890
  • Kuro-o M; Matsumura Y; Aizawa H; Kawaguchi H; Suga T; Utsugi T; Ohyama Y; Kurabayashi M; Kaname T; Kume E; Iwasaki H; Iida A; Shiraki-Iida T; Nishikawa S; Nagai R; Nabeshima YI
  • Nature 1997[Nov]; 390 (6655): 45-51 PMID9363890show ga
  • A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
  • |Aging/*genetics/pathology[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Arteriosclerosis/genetics/pathology[MESH]
  • |Atrophy[MESH]
  • |Calcinosis/genetics/pathology[MESH]
  • |Cloning, Molecular[MESH]
  • |Emphysema/genetics[MESH]
  • |Female[MESH]
  • |Genitalia/pathology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Membrane Proteins/*genetics/physiology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Mice, Inbred C3H[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mice, Transgenic[MESH]
  • |Molecular Sequence Data[MESH]
  • |Mutagenesis, Insertional[MESH]
  • |Osteoporosis/genetics/pathology[MESH]
  • |Phenotype[MESH]
  • |Pituitary Gland/pathology[MESH]
  • |Sequence Homology, Amino Acid[MESH]
  • |Skin/pathology[MESH]
  • |Syndrome[MESH]


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