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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nature 1997 ; 390 (6655): 45-51 Nephropedia Template TP
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing #MMPMID9363890
Kuro-o M; Matsumura Y; Aizawa H; Kawaguchi H; Suga T; Utsugi T; Ohyama Y; Kurabayashi M; Kaname T; Kume E; Iwasaki H; Iida A; Shiraki-Iida T; Nishikawa S; Nagai R; Nabeshima YI
Nature 1997[Nov]; 390 (6655): 45-51 PMID9363890show ga
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.