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10.1006/exnr.1997.6514

http://scihub22266oqcxt.onion/10.1006/exnr.1997.6514
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9225763!ä!9225763

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suck abstract from ncbi


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pmid9225763      Exp+Neurol 1997 ; 146 (1): 286-90
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  • Flow cytometric analysis of major histocompatibility complex (MHC) class II antigen expression on brain cells from Borna disease virus-infected rats without an intervening in vitro culture step #MMPMID9225763
  • Rubin SA; Park SW; Soloski MJ; Carbone KM
  • Exp Neurol 1997[Jul]; 146 (1): 286-90 PMID9225763show ga
  • Borna disease virus (BDV) infects astrocytes in the Lewis rat brain. BDV-infected astrocytes have been shown to express MHC class II in vitro but not in vivo. Using a sensitive fluorescence-activated cytometric technique, we now report the detection of MHC class II on freshly harvested S100-positive cells from BDV-infected rat brain, without an intervening in vitro culture step. These data support the hypothesis that astrocytes from BDV-infected rats express MHC class II on their surface and, thus, are potential participants in the encephalitic response to BDV infection.
  • |Animals[MESH]
  • |Astrocytes/*pathology[MESH]
  • |Borna Disease/*immunology/pathology[MESH]
  • |Borna disease virus/immunology[MESH]
  • |Brain/*immunology/pathology[MESH]
  • |Encephalitis, Viral/*immunology/pathology[MESH]
  • |Flow Cytometry/methods[MESH]
  • |Histocompatibility Antigens Class II/analysis/*biosynthesis[MESH]
  • |Immunohistochemistry/methods[MESH]
  • |Rats[MESH]
  • |S100 Proteins/analysis/biosynthesis[MESH]


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