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10.1007/s004010050630

http://scihub22266oqcxt.onion/10.1007/s004010050630
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9113204!7086795!9113204
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suck abstract from ncbi


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pmid9113204      Acta+Neuropathol 1997 ; 93 (4): 391-401
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  • Neurological disease and encephalitis in cats experimentally infected with Borna disease virus #MMPMID9113204
  • Lundgren AL; Johannisson A; Zimmermann W; Bode L; Rozell B; Muluneh A; Lindberg R; Ludwig H
  • Acta Neuropathol 1997[Apr]; 93 (4): 391-401 PMID9113204show ga
  • Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Three out of eight inoculated cats developed neurological signs and non-suppurative encephalitis; all three recovered from the acute stage of disease. Sero-conversion and the development of neutralizing antibodies occurred in all of the virus-inoculated cats. In addition, cats inoculated with feline BDV showed an early peripheral T cell response not present in cats inoculated with BDV strain V, suggesting that the feline virus exerted a more vigorous effect on the immune system. Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD.
  • |Animals[MESH]
  • |Antibodies, Viral/biosynthesis[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |Borna Disease/drug therapy/*pathology[MESH]
  • |Borna disease virus/genetics/immunology[MESH]
  • |Cat Diseases/*pathology[MESH]
  • |Cats[MESH]
  • |Cyclophosphamide/therapeutic use[MESH]
  • |DNA, Viral/analysis[MESH]
  • |Encephalitis, Viral/drug therapy/*pathology/*veterinary[MESH]
  • |Female[MESH]
  • |Immunity, Cellular[MESH]


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