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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Neurovirol 1997 ; 3 (2): 174-8 Nephropedia Template TP
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Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders #MMPMID9111180
Richt JA; Alexander RC; Herzog S; Hooper DC; Kean R; Spitsin S; Bechter K; Schuttler R; Feldmann H; Heiske A; Fu ZF; Dietzschold B; Rott R; Koprowski H
J Neurovirol 1997[Apr]; 3 (2): 174-8 PMID9111180show ga
The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies concerning the detection of BDV-specific RNA in blood cells from patients with psychiatric diseases. Contrary to the results obtained by others, we have found no evidence for the presence of BDV-RNA in such cells. Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.