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10.1002/(sici)1096-8628(19970110)68:1<12::aid-ajmg3>3.0.co;2-#

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suck abstract from ncbi


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pmid8986269      Am+J+Med+Genet 1997 ; 68 (1): 12-7
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  • Bronchopulmonary-foregut malformations: a continuum of paracrine hamartomas? #MMPMID8986269
  • Kousseff BG; Gilbert-Barness E; Debich-Spicer D
  • Am J Med Genet 1997[Jan]; 68 (1): 12-7 PMID8986269show ga
  • The bronchopulmonary-foregut malformations (BPFM) are usually sporadic, solitary cystic hamartomas involving conducting airways, arteries, venous drainage, and lung parenchyma. Transitional, compound hamartomas exist, and only their morphology is well-known. Between 1984-1994 we encountered and studied 10 unrelated patients and a stillborn infant with BPFM (out of 24,000 families). Ten were diagnosed in utero and one at birth as having congenital cystic adenomatoid malformation of the lung (CCAML). Postnatally, two diagnoses (20%) were corrected to bronchogenic cyst (BC) and diaphragmatic hernia, respectively. Bilateral lung involvement was present in 1 patient, and in 2 there was a considerable macroscopic regression of the hamartoma. Histologic studies of the six resected CCAML confirmed the diagnosis and implied dysregulated paracrine growth with its cellular and extracellular growth factors, protooncogenes, oncogenes, cytokines, cell-adhesive molecules, and receptors of these regulatory peptides, and their complex interactions as developmental morphogens in time and space.
  • |*Digestive System Abnormalities[MESH]
  • |Digestive System/pathology[MESH]
  • |Female[MESH]
  • |Fetal Death[MESH]
  • |Gastrointestinal Diseases/*genetics/pathology[MESH]
  • |Hamartoma/*genetics/pathology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Lung Diseases/*genetics/pathology[MESH]
  • |Lung/*abnormalities/pathology[MESH]


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