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10.1016/s0162-3109(96)00142-7

http://scihub22266oqcxt.onion/10.1016/s0162-3109(96)00142-7
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8956980!ä!8956980

suck abstract from ncbi


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pmid8956980      Immunopharmacology 1996 ; 35 (2): 163-9
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  • Protective effect of adenylate deaminase (from Penicillium lanoso-viride) against acute infections in mice #MMPMID8956980
  • Nikolajeva V; Eze D; Kamradze A; Indulena M; Muiznieks I
  • Immunopharmacology 1996[Nov]; 35 (2): 163-9 PMID8956980show ga
  • We examined the effects of the immunomodulator-adenylate deaminase (E.C. 3.5.4.6) from Penicillium lanoso-viride on experimental mice infections. Prophylactic intraperitoneal administration of adenylate deaminase (ADA) increased survival time and numbers of survivors after infection with Salmonella typhimurium, Pseudomonas aeruginosa and influenza A (H3N2) virus. Protection against influenza virus after intranasal ADA application was also observed. The influence of ADA was time and dose dependent. The most pronounced protection was obtained by administration of 3 U ADA/mice 24 h prior to infection. ADA had no antibiotic effect against these bacterial strains. Protective effects of ADA were studied in immunosuppressed mice under different regimes of treatment including cyclosporin A and trypan blue. The results indicated, that the protective effect of ADA is of a complex nature and probably depends on both T-cell and macrophage components.
  • |AMP Deaminase/*biosynthesis/*therapeutic use[MESH]
  • |Acute Disease[MESH]
  • |Animals[MESH]
  • |Female[MESH]
  • |Influenza A virus/drug effects[MESH]
  • |Mice[MESH]
  • |Mice, Inbred CBA[MESH]
  • |Mice, Inbred ICR[MESH]
  • |Orthomyxoviridae Infections/drug therapy/*prevention & control[MESH]
  • |Penicillium/*metabolism[MESH]
  • |Pseudomonas Infections/drug therapy/*prevention & control[MESH]
  • |Salmonella Infections, Animal/drug therapy/*prevention & control[MESH]


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