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10.1093/infdis/136.2.171 http://scihub22266oqcxt.onion/10.1093/infdis/136.2.171 894076!ä!894076 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 1977 ; 136 (2): 171-5 Nephropedia Template TP {{tp|p=894076|t=1977. Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guerin |pdf=|usr=}}{{894076}} gab.com Text Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guerin JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=894076 #FOAvip Bacille Calmette-Guerin (BCG) has been used effectively to protect nonspecifically against bacterial infections and neoplasms, probably by enhancement of cell-mediated immunity. It has been suggested that cell-mediated immunity plays a role in the host defense against certain viral infections. In recent in vitro studies, macrophages from animals sensitized by BCG were more effective in lowering the titer of influenza virus than were macrophages from control animals. The purpose of this study was to investigate the in vivo effectiveness of nonspecific immune stimulation with BCG on influenza virus infection in mice. Immunization with BCG resulted in significant protection of mice. Also, the local (nasal) route of immunization was more effective than the systemic (intraperitoneal) route against the intranasal inoculum of virus, a finding which suggests that important role of local immunity, i.e., either earlier stimulation of secretory antibody or nonspecific cell-mediated immunity. The time course of the resistance ot infection suggests that interferon was not the protective mechanism. Twit Text FOAVip Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guerin ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=894076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=894076 #FOAvip English Wikipedia <ref>{{Cite pmid|894076}}</ref> Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guerin #MMPMID894076 Spencer JC; Ganguly R; Waldman RH J Infect Dis 1977[Aug]; 136 (2): 171-5 PMID894076show ga Bacille Calmette-Guerin (BCG) has been used effectively to protect nonspecifically against bacterial infections and neoplasms, probably by enhancement of cell-mediated immunity. It has been suggested that cell-mediated immunity plays a role in the host defense against certain viral infections. In recent in vitro studies, macrophages from animals sensitized by BCG were more effective in lowering the titer of influenza virus than were macrophages from control animals. The purpose of this study was to investigate the in vivo effectiveness of nonspecific immune stimulation with BCG on influenza virus infection in mice. Immunization with BCG resulted in significant protection of mice. Also, the local (nasal) route of immunization was more effective than the systemic (intraperitoneal) route against the intranasal inoculum of virus, a finding which suggests that important role of local immunity, i.e., either earlier stimulation of secretory antibody or nonspecific cell-mediated immunity. The time course of the resistance ot infection suggests that interferon was not the protective mechanism. |*BCG Vaccine/administration & dosage[MESH] |Administration, Intranasal[MESH] |Animals[MESH] |Female[MESH] |Immunization, Secondary[MESH] |Injections, Intraperitoneal[MESH] |Mice[MESH] |Orthomyxoviridae Infections/*prevention & control[MESH] |Time Factors[MESH]Nonspecific protection of mice against influenza virus infection by lo(epmc).pdf DeepDyve Pubget Overpricing