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pmid8826660      Clin+Transplant 1996 ; 10 (3): 243-7
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  • Parvovirus B19 infection in a liver transplant recipient: case report and review in organ transplant recipients #MMPMID8826660
  • Chang FY; Singh N; Gayowski T; Marino IR
  • Clin Transplant 1996[Jun]; 10 (3): 243-7 PMID8826660show ga
  • We report an adult liver transplant recipient with parvovirus B19 infection, presenting as chronic transfusion-dependent anemia ensuing 1 month post-transplantation. Both serum and bone marrow cells were positive for parvovirus B19 DNA detected by polymerase chain reaction. The bone marrow biopsy revealed erythroid hypoplasia with a selective decrease of nucleated red cell precursors, and giant pronormoblasts with prominent intranuclear inclusions, characteristic of parvovirus B19 infection. Anemia and viremia resolved shortly after administration of immunoglobulin, suggesting a therapeutic role. This case and several similar ones in the literature provide justification for a controlled clinical trial of immunoglobulin for parvovirus-induced anemia in transplant recipients.
  • |*Liver Transplantation[MESH]
  • |*Parvovirus B19, Human[MESH]
  • |Adult[MESH]
  • |Anemia/etiology[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Male[MESH]
  • |Parvoviridae Infections/diagnosis/*etiology/therapy[MESH]


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