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10.1016/0165-5728(96)00083-5 http://scihub22266oqcxt.onion/10.1016/0165-5728(96)00083-5 8784266!ä!8784266 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroimmunol 1996 ; 68 (1-2): 101-8 Nephropedia Template TP {{tp|p=8784266|t=1996. Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons |pdf=|usr=}}{{8784266}} gab.com Text Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons JO: J Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=8784266 #FOAvip Type I NOS expression increases in OB neurons during VSV infection. Immunocytochemical staining of NB41A3 cells indicates constitutive expression of interferon (IFN)-gamma receptor and type I NOS. IFN-gamma treatment of NB41A3 cells increased NO production and type I NOS protein. In vitro replication of VSV, polio virus type I, and Herpes Simplex virus type I (HSV-1) is significantly inhibited by IFN-gamma induced type I NOS and antagonized by NOS inhibitors. In contrast, while IFN-gamma treatment inhibited influenza and Sindbis virus replication, a different pathway(s) was involved. The isoform-selective NOS inhibitor. 7-nitroindazole (7NI) was used to treat mice, resulting in a 10-fold higher titer of virus in brain homogenates, and abrogated the recovery-promoting effect of interleukin-12 treatment. Thus, IFN-gamma induced type I NOS activity may play an important role in host immunity against neurotropic viral infections. Twit Text FOAVip Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons ????J Neuroimmunol http://www.kidney.de/pget.php?&tw=1&pmid=8784266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8784266 #FOAvip English Wikipedia <ref>{{Cite pmid|8784266}}</ref> Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons #MMPMID8784266 Komatsu T; Bi Z; Reiss CS J Neuroimmunol 1996[Aug]; 68 (1-2): 101-8 PMID8784266show ga Type I NOS expression increases in OB neurons during VSV infection. Immunocytochemical staining of NB41A3 cells indicates constitutive expression of interferon (IFN)-gamma receptor and type I NOS. IFN-gamma treatment of NB41A3 cells increased NO production and type I NOS protein. In vitro replication of VSV, polio virus type I, and Herpes Simplex virus type I (HSV-1) is significantly inhibited by IFN-gamma induced type I NOS and antagonized by NOS inhibitors. In contrast, while IFN-gamma treatment inhibited influenza and Sindbis virus replication, a different pathway(s) was involved. The isoform-selective NOS inhibitor. 7-nitroindazole (7NI) was used to treat mice, resulting in a 10-fold higher titer of virus in brain homogenates, and abrogated the recovery-promoting effect of interleukin-12 treatment. Thus, IFN-gamma induced type I NOS activity may play an important role in host immunity against neurotropic viral infections. |Animals[MESH] |Astrocytoma[MESH] |Base Sequence[MESH] |Herpesvirus 1, Human/physiology[MESH] |Interferon-gamma/*pharmacology[MESH] |Macrophages/enzymology/immunology[MESH] |Mice[MESH] |Molecular Sequence Data[MESH] |Neuroblastoma[MESH] |Neurons/chemistry/*enzymology/*virology[MESH] |Nitric Oxide Synthase/immunology/*metabolism[MESH] |Nitric Oxide/biosynthesis[MESH] |Poliovirus/physiology[MESH] |Receptors, Interferon/analysis[MESH] |Tumor Cells, Cultured/enzymology/immunology[MESH] |Up-Regulation/immunology[MESH] |Vesicular stomatitis Indiana virus/physiology[MESH]Interferon-gamma induced type I nitric oxide synthase activity inhibit(epmc).pdf DeepDyve Pubget Overpricing