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10.1080/17843286.1996.11718489

http://scihub22266oqcxt.onion/10.1080/17843286.1996.11718489
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8693871!ä!8693871

suck abstract from ncbi


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pmid8693871      Acta+Clin+Belg 1996 ; 51 (2): 70-9
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  • In vitro activity of amoxycillin/clavulanate and ticarcillin/clavulanate compared with that of other antibiotics against anaerobic bacteria: comparison with the results of the 1987 survey #MMPMID8693871
  • Pierard D; De Meyer A; Rosseel P; Van Cauwenbergh M; Struelens MJ; Delmee M; Goossens H; Claeys G; Glupczynski Y; Verbist L; Melin P; Lauwers S
  • Acta Clin Belg 1996[]; 51 (2): 70-9 PMID8693871show ga
  • The activity of amoxycillin/clavulanate (Augmentin) and ticarcillin/ clavulanate (Timentin) was tested against 351 strict anaerobic clinical isolates collected from September 1993 to April 1994 in eight Belgian university hospitals and compared with that of 8 other antibiotics using the NCCLS reference agar dilution procedure. Production of beta-lactamase was detected by the nitrocefin test in 48% of the isolates. At NCCLS-recommended breakpoints, more than 90% of isolates were susceptible to amoxycillin/clavulanate, ticarcillin/clavulanate, piperacillin/tazobactam, imipenem, chloramphenicol and metronidazole but only 77%, 72% and 48% to cefoxitin, clindamycin and penicillin, respectively. In comparison with the results of a similar survey conducted in 1987 no major changes in susceptibility were observed except for the susceptibility to clindamycin that declined from 83% to 72% overall, and from 83% to 66% in the B. fragilis group. Furthermore one isolate of Clostridium clostridioforme was found produce beta-lactamase and few B. fragilis group isolates showed reduced susceptibility to metronidazole.
  • |Amoxicillin-Potassium Clavulanate Combination[MESH]
  • |Amoxicillin/pharmacology[MESH]
  • |Anti-Bacterial Agents/pharmacology[MESH]
  • |Bacteria, Anaerobic/*drug effects[MESH]
  • |Clavulanic Acids/pharmacology[MESH]
  • |Drug Therapy, Combination/*pharmacology[MESH]
  • |Microbial Sensitivity Tests[MESH]


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