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10.1038/379833a0 http://scihub22266oqcxt.onion/10.1038/379833a0 8587608!ä!8587608 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 1996 ; 379 (6568): 833-6 Nephropedia Template TP {{tp|p=8587608|t=1996. The inward rectification mechanism of the HERG cardiac potassium channel |pdf=|usr=}}{{8587608}} gab.com Text The inward rectification mechanism of the HERG cardiac potassium channel JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=8587608 #FOAvip A human genetic defect associated with 'long Q-T syndrome', an abnormality of cardiac rhythm involving the repolarization of the action potential, was recently found to lie in the HERG gene, which codes for a potassium channel. The HERG K+ channel is unusual in that it seems to have the architectural plan of the depolarization-activated K+ channel family (six putative transmembrane segments), yet it exhibits rectification like that of the inward-rectifying K+ channels, a family with different molecular structure (two transmembrane segments). We have studied HERG channels expressed in mammalian cells and find that this inward rectification arises from a rapid and voltage-dependent inactivation process that reduces conductance at positive voltages. The inactivation gating mechanism resembles that of C-type inactivation, often considered to be the 'slow inactivation' mechanism of other K+ channels. The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias. Twit Text FOAVip The inward rectification mechanism of the HERG cardiac potassium channel ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=8587608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8587608 #FOAvip English Wikipedia <ref>{{Cite pmid|8587608}}</ref> The inward rectification mechanism of the HERG cardiac potassium channel #MMPMID8587608 Smith PL; Baukrowitz T; Yellen G Nature 1996[Feb]; 379 (6568): 833-6 PMID8587608show ga A human genetic defect associated with 'long Q-T syndrome', an abnormality of cardiac rhythm involving the repolarization of the action potential, was recently found to lie in the HERG gene, which codes for a potassium channel. The HERG K+ channel is unusual in that it seems to have the architectural plan of the depolarization-activated K+ channel family (six putative transmembrane segments), yet it exhibits rectification like that of the inward-rectifying K+ channels, a family with different molecular structure (two transmembrane segments). We have studied HERG channels expressed in mammalian cells and find that this inward rectification arises from a rapid and voltage-dependent inactivation process that reduces conductance at positive voltages. The inactivation gating mechanism resembles that of C-type inactivation, often considered to be the 'slow inactivation' mechanism of other K+ channels. The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias. |*Cation Transport Proteins[MESH] |*DNA-Binding Proteins[MESH] |*Potassium Channels, Voltage-Gated[MESH] |*Trans-Activators[MESH] |Animals[MESH] |Arrhythmias, Cardiac/metabolism[MESH] |Cell Line[MESH] |Drosophila[MESH] |Drosophila Proteins[MESH] |ERG1 Potassium Channel[MESH] |Ether-A-Go-Go Potassium Channels[MESH] |Humans[MESH] |Ion Channel Gating[MESH] |Long QT Syndrome/metabolism[MESH] |Magnesium/pharmacology[MESH] |Membrane Potentials[MESH] |Mutation[MESH] |Myocardium/*metabolism[MESH] |Potassium Channel Blockers[MESH] |Potassium Channels/genetics/*metabolism[MESH] |Recombinant Proteins[MESH] |Shaker Superfamily of Potassium Channels[MESH] |Tetraethylammonium[MESH] |Tetraethylammonium Compounds/pharmacology[MESH]The inward rectification mechanism of the HERG cardiac potassium chann(epmc).pdf DeepDyve Pubget Overpricing